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Discovery of Novel NLRP3 Inflammasome Inhibitors Composed of an Oxazole Scaffold Bearing an Acylsulfamide.
Ohba Y, Adachi K, Furukawa T, Nishimaru T, Sakurai K, Masuo R, Inami T, Orita T, Akai S, Adachi T, Usui K, Hamada Y, Mori M, Kurimoto T, Wakashima T, Akiyama Y, Miyazaki S, Noji S. Ohba Y, et al. Among authors: hamada y. ACS Med Chem Lett. 2023 Nov 10;14(12):1833-1838. doi: 10.1021/acsmedchemlett.3c00433. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116417
Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoroethoxy)pyridin-3-yl]-3,4-dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel transient receptor potential vanilloid 1 antagonist.
Kitagawa Y, Miyai A, Usui K, Hamada Y, Deai K, Wada M, Koga Y, Sakata M, Hayashi M, Tominaga M, Matsushita M. Kitagawa Y, et al. Among authors: hamada y. J Pharmacol Exp Ther. 2012 Aug;342(2):520-8. doi: 10.1124/jpet.112.194027. Epub 2012 May 15. J Pharmacol Exp Ther. 2012. PMID: 22588258
Janus kinase inhibitor delgocitinib suppresses pruritus and nerve elongation in an atopic dermatitis murine model.
Yamamoto Y, Otsuka A, Nakashima C, Ishida Y, Honda T, Egawa G, Amano W, Usui K, Hamada Y, Wada M, Tanimoto A, Konishi N, Hayashi M, Matsushita M, Kabashima K. Yamamoto Y, et al. Among authors: hamada y. J Dermatol Sci. 2020 Feb;97(2):161-164. doi: 10.1016/j.jdermsci.2019.12.008. Epub 2019 Dec 20. J Dermatol Sci. 2020. PMID: 31924380 No abstract available.
2,026 results