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The multiplex network of human diseases.
Halu A, De Domenico M, Arenas A, Sharma A. Halu A, et al. NPJ Syst Biol Appl. 2019 Apr 23;5:15. doi: 10.1038/s41540-019-0092-5. eCollection 2019. NPJ Syst Biol Appl. 2019. PMID: 31044086 Free PMC article.
PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. Iwata H, et al. Among authors: halu a. Nat Commun. 2016 Oct 31;7:12849. doi: 10.1038/ncomms12849. Nat Commun. 2016. PMID: 27796300 Free PMC article.
Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.
Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Schlotter F, et al. Among authors: halu a. Circulation. 2018 Jul 24;138(4):377-393. doi: 10.1161/CIRCULATIONAHA.117.032291. Circulation. 2018. PMID: 29588317 Free PMC article.
Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.
Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J. Sharma A, et al. Among authors: halu a. NPJ Syst Biol Appl. 2018 Jul 3;4:25. doi: 10.1038/s41540-018-0057-0. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29977601 Free PMC article.
Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation.
Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A. Halu A, et al. Elife. 2018 Oct 10;7:e37059. doi: 10.7554/eLife.37059. Elife. 2018. PMID: 30303482 Free PMC article.
Many different proteins interact with each other to control inflammation; gaining an insight into the nature of these interactions could help to pinpoint the role of each molecular actor. Researchers have used a combination of unbiased, large-scale experimental and computa …
Many different proteins interact with each other to control inflammation; gaining an insight into the nature of these interactions could hel …
Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.
Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Nakano T, et al. Among authors: halu a. Circulation. 2019 Jan 2;139(1):78-96. doi: 10.1161/CIRCULATIONAHA.118.034588. Circulation. 2019. PMID: 30586693 Free PMC article.
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