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Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes.
J Immunol. 2019 Mar 1;202(5):1521-1530. doi: 10.4049/jimmunol.1800912. Epub 2019 Jan 30.
J Immunol. 2019.
PMID: 30700584
The hypoxia-inducible factor (HIF) couples immunity with metabolism.
Halligan DN, Murphy SJ, Taylor CT.
Halligan DN, et al.
Semin Immunol. 2016 Oct;28(5):469-477. doi: 10.1016/j.smim.2016.09.004. Epub 2016 Oct 4.
Semin Immunol. 2016.
PMID: 27717536
Review.
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FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1.
Scholz CC, Rodriguez J, Pickel C, Burr S, Fabrizio JA, Nolan KA, Spielmann P, Cavadas MA, Crifo B, Halligan DN, Nathan JA, Peet DJ, Wenger RH, Von Kriegsheim A, Cummins EP, Taylor CT.
Scholz CC, et al. Among authors: halligan dn.
PLoS Biol. 2016 Jan 11;14(1):e1002347. doi: 10.1371/journal.pbio.1002347. eCollection 2016 Jan.
PLoS Biol. 2016.
PMID: 26752685
Free PMC article.
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Pharmacologic inhibition of hypoxia-inducible factor (HIF)-hydroxylases ameliorates allergic contact dermatitis.
Manresa MC, Smith L, Casals-Diaz L, Fagundes RR, Brown E, Radhakrishnan P, Murphy SJ, Crifo B, Strowitzki MJ, Halligan DN, van den Bogaard EH, Niehues H, Schneider M, Taylor CT, Steinhoff M.
Manresa MC, et al. Among authors: halligan dn.
Allergy. 2019 Apr;74(4):753-766. doi: 10.1111/all.13655. Epub 2018 Dec 12.
Allergy. 2019.
PMID: 30394557
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Hypoxia-inducible factor hydroxylase inhibition enhances the protective effects of cyclosporine in colitis.
Halligan DN, Khan MN, Brown E, Rowan CR, Coulter IS, Doherty GA, Tambuwala MM, Taylor CT.
Halligan DN, et al.
Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G90-G97. doi: 10.1152/ajpgi.00049.2019. Epub 2019 May 9.
Am J Physiol Gastrointest Liver Physiol. 2019.
PMID: 31070931
Free article.
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Prolyl Hydroxylase Inhibition Mitigates Pouchitis.
Harnoss JM, Gebhardt JM, Radhakrishnan P, Leowardi C, Burmeister J, Halligan DN, Yuan S, Kennel KB, Strowitzki MJ, Schaible A, Lasitschka F, Taylor CT, Schneider M.
Harnoss JM, et al. Among authors: halligan dn.
Inflamm Bowel Dis. 2020 Jan 6;26(2):192-205. doi: 10.1093/ibd/izz218.
Inflamm Bowel Dis. 2020.
PMID: 31618435
Review.
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Mucosal inflammation downregulates PHD1 expression promoting a barrier-protective HIF-1α response in ulcerative colitis patients.
Brown E, Rowan C, Strowitzki MJ, Fagundes RR, Faber KN, Güntsch A, Halligan DN, Kugler J, Jones F, Lee CT, Doherty G, Taylor CT.
Brown E, et al. Among authors: halligan dn.
FASEB J. 2020 Mar;34(3):3732-3742. doi: 10.1096/fj.201902103R. Epub 2020 Jan 16.
FASEB J. 2020.
PMID: 31944416
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