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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N. Richetin K, et al. Among authors: halliez s. Nat Neurosci. 2020 Dec;23(12):1567-1579. doi: 10.1038/s41593-020-00728-x. Epub 2020 Nov 9. Nat Neurosci. 2020. PMID: 33169029
Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost α2-adrenergic receptor agonistic activity.
Nguyen PH, Hammoud H, Halliez S, Pang Y, Evrard J, Schmitt M, Oumata N, Bourguignon JJ, Sanyal S, Beringue V, Blondel M, Bihel F, Voisset C. Nguyen PH, et al. Among authors: halliez s. ACS Chem Neurosci. 2014 Oct 15;5(10):1075-82. doi: 10.1021/cn5001588. Epub 2014 Sep 22. ACS Chem Neurosci. 2014. PMID: 25244284
24 results