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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality.
Cancer Cell. 2019 May 13;35(5):721-737.e9. doi: 10.1016/j.ccell.2019.03.014. Epub 2019 May 2.
Cancer Cell. 2019.
PMID: 31056398
Free PMC article.
Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia.
Barghout SH, Patel PS, Wang X, Xu GW, Kavanagh S, Halgas O, Zarabi SF, Gronda M, Hurren R, Jeyaraju DV, MacLean N, Brennan S, Hyer ML, Berger A, Traore T, Milhollen M, Smith AC, Minden MD, Pai EF, Hakem R, Schimmer AD.
Barghout SH, et al. Among authors: halgas o.
Leukemia. 2019 Jan;33(1):37-51. doi: 10.1038/s41375-018-0167-0. Epub 2018 Jun 8.
Leukemia. 2019.
PMID: 29884901
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The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling.
Ghodrati F, Mehrabian M, Williams D, Halgas O, Bourkas MEC, Watts JC, Pai EF, Schmitt-Ulms G.
Ghodrati F, et al. Among authors: halgas o.
Sci Rep. 2018 Jun 5;8(1):8654. doi: 10.1038/s41598-018-26685-x.
Sci Rep. 2018.
PMID: 29872131
Free PMC article.
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Defluorination Capability of l-2-Haloacid Dehalogenases in the HAD-Like Hydrolase Superfamily Correlates with Active Site Compactness.
Chan PWY, Chakrabarti N, Ing C, Halgas O, To TKW, Wälti M, Petit AP, Tran C, Savchenko A, Yakunin AF, Edwards EA, Pomès R, Pai EF.
Chan PWY, et al. Among authors: halgas o.
Chembiochem. 2022 Jan 5;23(1):e202100414. doi: 10.1002/cbic.202100414. Epub 2021 Oct 22.
Chembiochem. 2022.
PMID: 34643018
Free PMC article.
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Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.
De Gasparo R, Halgas O, Harangozo D, Kaiser M, Pai EF, Krauth-Siegel RL, Diederich F.
De Gasparo R, et al. Among authors: halgas o.
Chemistry. 2019 Sep 2;25(49):11416-11421. doi: 10.1002/chem.201901664. Epub 2019 Aug 13.
Chemistry. 2019.
PMID: 31407832
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Engineering a murine cell line for the stable propagation of hamster prions.
Bourkas MEC, Arshad H, Al-Azzawi ZAM, Halgas O, Shikiya RA, Mehrabian M, Schmitt-Ulms G, Bartz JC, Watts JC.
Bourkas MEC, et al. Among authors: halgas o.
J Biol Chem. 2019 Mar 29;294(13):4911-4923. doi: 10.1074/jbc.RA118.007135. Epub 2019 Jan 31.
J Biol Chem. 2019.
PMID: 30705093
Free PMC article.
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