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Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression.
Canet-Pons J, Sen NE, Arsović A, Almaguer-Mederos LE, Halbach MV, Key J, Döring C, Kerksiek A, Picchiarelli G, Cassel R, René F, Dieterlé S, Fuchs NV, König R, Dupuis L, Lütjohann D, Gispert S, Auburger G. Canet-Pons J, et al. Among authors: halbach mv. Neurobiol Dis. 2021 May;152:105289. doi: 10.1016/j.nbd.2021.105289. Epub 2021 Feb 10. Neurobiol Dis. 2021. PMID: 33577922 Free article.
Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation.
Sen NE, Canet-Pons J, Halbach MV, Arsovic A, Pilatus U, Chae WH, Kaya ZE, Seidel K, Rollmann E, Mittelbronn M, Meierhofer D, De Zeeuw CI, Bosman LWJ, Gispert S, Auburger G. Sen NE, et al. Among authors: halbach mv. Neurobiol Dis. 2019 Dec;132:104559. doi: 10.1016/j.nbd.2019.104559. Epub 2019 Jul 31. Neurobiol Dis. 2019. PMID: 31376479 Free article.