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Draining the FEN1s for cancer therapy.
Rossetti GG, Sotiriou SK, Halazonetis TD. Rossetti GG, et al. Among authors: halazonetis td. Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):21849-21850. doi: 10.1073/pnas.2014862117. Epub 2020 Aug 18. Proc Natl Acad Sci U S A. 2020. PMID: 32817488 Free PMC article. No abstract available.
Non-covalent SARS-CoV-2 Mpro inhibitors developed from in silico screen hits.
Rossetti GG, Ossorio MA, Rempel S, Kratzel A, Dionellis VS, Barriot S, Tropia L, Gorgulla C, Arthanari H, Thiel V, Mohr P, Gamboni R, Halazonetis TD. Rossetti GG, et al. Among authors: halazonetis td. Sci Rep. 2022 Feb 15;12(1):2505. doi: 10.1038/s41598-022-06306-4. Sci Rep. 2022. PMID: 35169179 Free PMC article.
Beating cancer one carbon at a time.
Dionellis VS, Halazonetis TD. Dionellis VS, et al. Among authors: halazonetis td. Nat Cancer. 2022 Feb;3(2):141-142. doi: 10.1038/s43018-022-00333-w. Nat Cancer. 2022. PMID: 35228750 No abstract available.
RAD51 protects human cells from transcription-replication conflicts.
Bhowmick R, Lerdrup M, Gadi SA, Rossetti GG, Singh MI, Liu Y, Halazonetis TD, Hickson ID. Bhowmick R, et al. Among authors: halazonetis td. Mol Cell. 2022 Sep 15;82(18):3366-3381.e9. doi: 10.1016/j.molcel.2022.07.010. Epub 2022 Aug 23. Mol Cell. 2022. PMID: 36002000 Free article.
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.
Groelly FJ, Dagg RA, Petropoulos M, Rossetti GG, Prasad B, Panagopoulos A, Paulsen T, Karamichali A, Jones SE, Ochs F, Dionellis VS, Puig Lombardi E, Miossec MJ, Lockstone H, Legube G, Blackford AN, Altmeyer M, Halazonetis TD, Tarsounas M. Groelly FJ, et al. Among authors: halazonetis td. Mol Cell. 2022 Sep 15;82(18):3382-3397.e7. doi: 10.1016/j.molcel.2022.07.011. Epub 2022 Aug 23. Mol Cell. 2022. PMID: 36002001 Free PMC article.
Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage.
Petropoulos M, Champeris Tsaniras S, Nikou S, Maxouri S, Dionellis VS, Kalogeropoulou A, Karamichali A, Ioannidis K, Danalatos IR, Obst M, Naumann R, Delinasios GJ, Gorgoulis VG, Roukos V, Anastassiadis K, Halazonetis TD, Bravou V, Lygerou Z, Taraviras S. Petropoulos M, et al. Among authors: halazonetis td. J Pathol. 2023 Jan;259(1):10-20. doi: 10.1002/path.6017. Epub 2022 Nov 9. J Pathol. 2023. PMID: 36210634
Transcription-replication conflicts underlie sensitivity to PARP inhibitors.
Petropoulos M, Karamichali A, Rossetti GG, Freudenmann A, Iacovino LG, Dionellis VS, Sotiriou SK, Halazonetis TD. Petropoulos M, et al. Among authors: halazonetis td. Nature. 2024 Apr;628(8007):433-441. doi: 10.1038/s41586-024-07217-2. Epub 2024 Mar 20. Nature. 2024. PMID: 38509368 Free PMC article.
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