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RNF168 regulates R-loop resolution and genomic stability in BRCA1/2-deficient tumors.
Patel PS, Abraham KJ, Guturi KKN, Halaby MJ, Khan Z, Palomero L, Ho B, Duan S, St-Germain J, Algouneh A, Mateo F, El Ghamrasni S, Barbour H, Barnes DR, Beesley J, Sanchez O, Berman HK, Brown GW, Affar EB, Chenevix-Trench G, Antoniou AC, Arrowsmith CH, Raught B, Pujana MA, Mekhail K, Hakem A, Hakem R. Patel PS, et al. Among authors: hakem a, hakem r. J Clin Invest. 2021 Feb 1;131(3):e140105. doi: 10.1172/JCI140105. J Clin Invest. 2021. PMID: 33529165 Free PMC article.
Brca1 required for T cell lineage development but not TCR loci rearrangement.
Mak TW, Hakem A, McPherson JP, Shehabeldin A, Zablocki E, Migon E, Duncan GS, Bouchard D, Wakeham A, Cheung A, Karaskova J, Sarosi I, Squire J, Marth J, Hakem R. Mak TW, et al. Among authors: hakem a, hakem r. Nat Immunol. 2000 Jul;1(1):77-82. doi: 10.1038/76950. Nat Immunol. 2000. PMID: 10881179
Collaboration of Brca1 and Chk2 in tumorigenesis.
McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R. McPherson JP, et al. Among authors: hakem a, hakem r. Genes Dev. 2004 May 15;18(10):1144-53. doi: 10.1101/gad.1192704. Epub 2004 May 6. Genes Dev. 2004. PMID: 15131084 Free PMC article.
Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.
McPherson JP, Tamblyn L, Elia A, Migon E, Shehabeldin A, Matysiak-Zablocki E, Lemmers B, Salmena L, Hakem A, Fish J, Kassam F, Squire J, Bruneau BG, Hande MP, Hakem R. McPherson JP, et al. Among authors: hakem a, hakem r. EMBO J. 2004 Sep 15;23(18):3677-88. doi: 10.1038/sj.emboj.7600371. Epub 2004 Sep 2. EMBO J. 2004. PMID: 15343267 Free PMC article.
Essential role for caspase-8 in Toll-like receptors and NFkappaB signaling.
Lemmers B, Salmena L, Bidère N, Su H, Matysiak-Zablocki E, Murakami K, Ohashi PS, Jurisicova A, Lenardo M, Hakem R, Hakem A. Lemmers B, et al. Among authors: hakem a, hakem r. J Biol Chem. 2007 Mar 9;282(10):7416-23. doi: 10.1074/jbc.M606721200. Epub 2007 Jan 9. J Biol Chem. 2007. PMID: 17213198 Free article.
Functional interplay of p53 and Mus81 in DNA damage responses and cancer.
Pamidi A, Cardoso R, Hakem A, Matysiak-Zablocki E, Poonepalli A, Tamblyn L, Perez-Ordonez B, Hande MP, Sanchez O, Hakem R. Pamidi A, et al. Among authors: hakem a, hakem r. Cancer Res. 2007 Sep 15;67(18):8527-35. doi: 10.1158/0008-5472.CAN-07-1161. Cancer Res. 2007. PMID: 17875692
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