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Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity.
Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Kim D, et al. Among authors: haggarty sj. Neuron. 2008 Dec 10;60(5):803-17. doi: 10.1016/j.neuron.2008.10.015. Neuron. 2008. PMID: 19081376 Free PMC article.
HDAC2 negatively regulates memory formation and synaptic plasticity.
Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. Guan JS, et al. Among authors: haggarty sj. Nature. 2009 May 7;459(7243):55-60. doi: 10.1038/nature07925. Nature. 2009. PMID: 19424149 Free PMC article.
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. Gräff J, et al. Among authors: haggarty sj. Nature. 2012 Feb 29;483(7388):222-6. doi: 10.1038/nature10849. Nature. 2012. PMID: 22388814 Free PMC article.
Brain-penetrant LSD1 inhibitors can block memory consolidation.
Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Neelamegam R, et al. Among authors: haggarty sj. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128. doi: 10.1021/cn200104y. Epub 2011 Oct 18. ACS Chem Neurosci. 2012. PMID: 22754608 Free PMC article.
Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity.
Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Fass DM, et al. Among authors: haggarty sj. Neuropharmacology. 2013 Jan;64:81-96. doi: 10.1016/j.neuropharm.2012.06.043. Epub 2012 Jul 4. Neuropharmacology. 2013. PMID: 22771460 Free PMC article.
166 results