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Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca2+ entry and accelerated differentiation.
Hewitt T, Alural B, Tilak M, Wang J, Becke N, Chartley E, Perreault M, Haggarty SJ, Sheridan SD, Perlis RH, Jones N, Mellios N, Lalonde J. Hewitt T, et al. Among authors: haggarty sj. Mol Psychiatry. 2023 Dec;28(12):5237-5250. doi: 10.1038/s41380-023-02152-6. Epub 2023 Jul 4. Mol Psychiatry. 2023. PMID: 37402854 Free PMC article.
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy.
Eteläinen TS, Silva MC, Uhari-Väänänen JK, De Lorenzo F, Jäntti MH, Cui H, Chavero-Pieres M, Kilpeläinen T, Mechtler C, Svarcbahs R, Seppälä E, Savinainen JR, Puris E, Fricker G, Gynther M, Julku UH, Huttunen HJ, Haggarty SJ, Myöhänen TT. Eteläinen TS, et al. Among authors: haggarty sj. Sci Transl Med. 2023 Apr 12;15(691):eabq2915. doi: 10.1126/scitranslmed.abq2915. Epub 2023 Apr 12. Sci Transl Med. 2023. PMID: 37043557
Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease.
Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Bradner JE, et al. Among authors: haggarty sj. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12617-22. doi: 10.1073/pnas.1006774107. Epub 2010 Jun 28. Proc Natl Acad Sci U S A. 2010. PMID: 20616024 Free PMC article.
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.
Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. Kuai L, et al. Among authors: haggarty sj. Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017. Chem Biol. 2011. PMID: 21802010 Free PMC article.
166 results