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Thiosemicarbazone Derivatives Developed to Overcome COTI-2 Resistance.
Pósa V, Stefanelli A, Nunes JHB, Hager S, Mathuber M, May NV, Berger W, Keppler BK, Kowol CR, Enyedy ÉA, Heffeter P. Pósa V, et al. Among authors: hager s. Cancers (Basel). 2022 Sep 14;14(18):4455. doi: 10.3390/cancers14184455. Cancers (Basel). 2022. PMID: 36139615 Free PMC article.
EGFR-targeting peptide-coupled platinum(IV) complexes.
Mayr J, Hager S, Koblmüller B, Klose MHM, Holste K, Fischer B, Pelivan K, Berger W, Heffeter P, Kowol CR, Keppler BK. Mayr J, et al. Among authors: hager s. J Biol Inorg Chem. 2017 Jun;22(4):591-603. doi: 10.1007/s00775-017-1450-7. Epub 2017 Apr 12. J Biol Inorg Chem. 2017. PMID: 28405842 Free PMC article.
The thiosemicarbazone Me2NNMe2 induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition.
Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakács G, Keppler BK, Berger W, Kowol CR, Heffeter P. Hager S, et al. Cell Death Dis. 2018 Oct 15;9(11):1052. doi: 10.1038/s41419-018-1102-z. Cell Death Dis. 2018. PMID: 30323190 Free PMC article.
High Copper Complex Stability and Slow Reduction Kinetics as Key Parameters for Improved Activity, Paraptosis Induction, and Impact on Drug-Resistant Cells of Anticancer Thiosemicarbazones.
Hager S, Pape VFS, Pósa V, Montsch B, Uhlik L, Szakács G, Tóth S, Jabronka N, Keppler BK, Kowol CR, Enyedy ÉA, Heffeter P. Hager S, et al. Antioxid Redox Signal. 2020 Aug 20;33(6):395-414. doi: 10.1089/ars.2019.7854. Epub 2020 Jun 9. Antioxid Redox Signal. 2020. PMID: 32336116
Cancer Cell Resistance Against the Clinically Investigated Thiosemicarbazone COTI-2 Is Based on Formation of Intracellular Copper Complex Glutathione Adducts and ABCC1-Mediated Efflux.
Bormio Nunes JH, Hager S, Mathuber M, Pósa V, Roller A, Enyedy ÉA, Stefanelli A, Berger W, Keppler BK, Heffeter P, Kowol CR. Bormio Nunes JH, et al. Among authors: hager s. J Med Chem. 2020 Nov 25;63(22):13719-13732. doi: 10.1021/acs.jmedchem.0c01277. Epub 2020 Nov 15. J Med Chem. 2020. PMID: 33190481 Free PMC article.
144 results