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FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes.
de Poel E, Spelier S, Hagemeijer MC, van Mourik P, Suen SWF, Vonk AM, Brunsveld JE, Ithakisiou GN, Kruisselbrink E, Oppelaar H, Berkers G, de Winter de Groot KM, Heida-Michel S, Jans SR, van Panhuis H, Bakker M, van der Meer R, Roukema J, Dompeling E, Weersink EJM, Koppelman GH, Blaazer AR, Muijlwijk-Koezen JE, van der Ent CK, Beekman JM. de Poel E, et al. Among authors: hagemeijer mc. J Cyst Fibros. 2023 May;22(3):548-559. doi: 10.1016/j.jcf.2023.03.004. Epub 2023 May 3. J Cyst Fibros. 2023. PMID: 37147251
Targeted locus amplification reveals heterogeneity between and within CFTR genotypes and association with CFTR function in patient-derived intestinal organoids.
Lefferts JW, Boersma V, Nieuwenhuijze NDA, Suen SWF, Hajo K, Collantes NS, Vermeulen C, Groeneweg T, Hagemeijer MC, de Jonge HR, van der Ent CK, Splinter E, Beekman JM. Lefferts JW, et al. Among authors: hagemeijer mc. J Cyst Fibros. 2023 May;22(3):538-547. doi: 10.1016/j.jcf.2023.04.003. Epub 2023 Apr 24. J Cyst Fibros. 2023. PMID: 37100706
Targeted Locus Amplification and Haplotyping.
Lefferts JW, Boersma V, Hagemeijer MC, Hajo K, Beekman JM, Splinter E. Lefferts JW, et al. Among authors: hagemeijer mc. Methods Mol Biol. 2023;2590:31-48. doi: 10.1007/978-1-0716-2819-5_2. Methods Mol Biol. 2023. PMID: 36335490
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.
Muilwijk D, de Poel E, van Mourik P, Suen SWF, Vonk AM, Brunsveld JE, Kruisselbrink E, Oppelaar H, Hagemeijer MC, Berkers G, de Winter-de Groot KM, Heida-Michel S, Jans SR, van Panhuis H, van der Eerden MM, van der Meer R, Roukema J, Dompeling E, Weersink EJM, Koppelman GH, Vries R, Zomer-van Ommen DD, Eijkemans MJC, van der Ent CK, Beekman JM. Muilwijk D, et al. Among authors: hagemeijer mc. Eur Respir J. 2022 Aug 18;60(2):2100508. doi: 10.1183/13993003.00508-2021. Print 2022 Aug. Eur Respir J. 2022. PMID: 35086832 Free PMC article.
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