Hagedorn PH - Search Results

1

Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.

Easton A, Jensen ML, Wang C, Hagedorn PH, Li Y, Weed M, Meredith JE, Guss V, Jones K, Gill M, Krause C, Brown JM, Hunihan L, Natale J, Fernandes A, Lu Y, Polino J, Bookbinder M, Cadelina G, Benitex Y, Sane R, Morrison J, Drexler D, Mercer SE, Bon C, Pandya NJ, Jagasia R, Ou Yang TH, Distler T, Grüninger F, Meldgaard M, Terrigno M, Macor JE, Albright CF, Loy J, Hoeg AM, Olson RE, Cacace AM. Easton A, et al. Among authors: hagedorn ph. Mol Ther Nucleic Acids. 2022 Aug 4;29:625-642. doi: 10.1016/j.omtn.2022.07.027. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 36090761 Free PMC article.

2

Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.

Anderson BR, Jensen ML, Hagedorn PH, Little SC, Olson RE, Ammar R, Kienzle B, Thompson J, McDonald I, Mercer S, Vikesaa J, Nordbo B, Iben L, Cao Y, Natale J, Dalton-Kay G, Cacace A, Hansen BR, Hedtjärn M, Koch T, Bristow LJ. Anderson BR, et al. Among authors: hagedorn ph. Mol Ther Nucleic Acids. 2020 Mar 6;19:1290-1298. doi: 10.1016/j.omtn.2020.01.012. Epub 2020 Jan 21. Mol Ther Nucleic Acids. 2020. PMID: 32092825 Free PMC article.

3

Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.

Hagedorn PH, Brown JM, Easton A, Pierdomenico M, Jones K, Olson RE, Mercer SE, Li D, Loy J, Høg AM, Jensen ML, Gill M, Cacace AM. Hagedorn PH, et al. Nucleic Acid Ther. 2022 Jun;32(3):151-162. doi: 10.1089/nat.2021.0071. Epub 2022 Feb 14. Nucleic Acid Ther. 2022. PMID: 35166597 Free PMC article.

4

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Hagedorn PH, Pontoppidan M, Bisgaard TS, Berrera M, Dieckmann A, Ebeling M, Møller MR, Hudlebusch H, Jensen ML, Hansen HF, Koch T, Lindow M. Hagedorn PH, et al. Nucleic Acids Res. 2018 Jun 20;46(11):5366-5380. doi: 10.1093/nar/gky397. Nucleic Acids Res. 2018. PMID: 29790953 Free PMC article.

5

Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties.

Papargyri N, Pontoppidan M, Andersen MR, Koch T, Hagedorn PH. Papargyri N, et al. Among authors: hagedorn ph. Mol Ther Nucleic Acids. 2020 Mar 6;19:706-717. doi: 10.1016/j.omtn.2019.12.011. Epub 2019 Dec 18. Mol Ther Nucleic Acids. 2020. PMID: 31951854 Free PMC article.

6

Targeting Repeated Regions Unique to a Gene Is an Effective Strategy for Discovering Potent and Efficacious Antisense Oligonucleotides.

Pedersen L, Hagedorn P, Vikeså J, Karlsen ST, Særmark P, Koch T, Lindow M. Pedersen L, et al. Mol Ther Nucleic Acids. 2020 Mar 6;19:124-131. doi: 10.1016/j.omtn.2019.10.040. Epub 2019 Nov 15. Mol Ther Nucleic Acids. 2020. PMID: 31846799 Free PMC article.

7

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Hagedorn PH, Yakimov V, Ottosen S, Kammler S, Nielsen NF, Høg AM, Hedtjärn M, Meldgaard M, Møller MR, Orum H, Koch T, Lindow M. Hagedorn PH, et al. Nucleic Acid Ther. 2013 Oct;23(5):302-10. doi: 10.1089/nat.2013.0436. Epub 2013 Aug 16. Nucleic Acid Ther. 2013. PMID: 23952551 Free PMC article.

8

A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides.

Dieckmann A, Hagedorn PH, Burki Y, Brügmann C, Berrera M, Ebeling M, Singer T, Schuler F. Dieckmann A, et al. Among authors: hagedorn ph. Mol Ther Nucleic Acids. 2018 Mar 2;10:45-54. doi: 10.1016/j.omtn.2017.11.004. Epub 2017 Nov 14. Mol Ther Nucleic Acids. 2018. PMID: 29499955 Free PMC article.

9

RNase H sequence preferences influence antisense oligonucleotide efficiency.

Kielpinski LJ, Hagedorn PH, Lindow M, Vinther J. Kielpinski LJ, et al. Among authors: hagedorn ph. Nucleic Acids Res. 2017 Dec 15;45(22):12932-12944. doi: 10.1093/nar/gkx1073. Nucleic Acids Res. 2017. PMID: 29126318 Free PMC article.

10

RNase H sequence preferences influence antisense oligonucleotide efficiency.

Kiełpiński ŁJ, Hagedorn PH, Lindow M, Vinther J. Kiełpiński ŁJ, et al. Among authors: hagedorn ph. Nucleic Acids Res. 2019 Mar 18;47(5):2701. doi: 10.1093/nar/gkz065. Nucleic Acids Res. 2019. PMID: 30715421 Free PMC article. No abstract available.

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