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The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats.
Foley AG, Hirst WD, Gallagher HC, Barry C, Hagan JJ, Upton N, Walsh FS, Hunter AJ, Regan CM. Foley AG, et al. Among authors: hagan jj. Neuropharmacology. 2008 Jun;54(8):1166-74. doi: 10.1016/j.neuropharm.2008.03.012. Epub 2008 Apr 1. Neuropharmacology. 2008. PMID: 18455201
Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.
Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR. Hagan JJ, et al. Br J Pharmacol. 2000 Jun;130(3):539-48. doi: 10.1038/sj.bjp.0703357. Br J Pharmacol. 2000. PMID: 10821781 Free PMC article.
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, Upton N. Hagan JJ, et al. Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10911-6. doi: 10.1073/pnas.96.19.10911. Proc Natl Acad Sci U S A. 1999. PMID: 10485925 Free PMC article.
SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'methyl-4'-(5-methyl-1,2,3-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): a novel, potent and selective 5-HT1B receptor antagonist.
Scott C, Langmead CJ, Clarke KL, Wyman P, Smith PW, Starr KR, Dawson LA, Price GW, Hagan JJ, Watson J. Scott C, et al. Among authors: hagan jj. Neuropharmacology. 2006 Jun;50(8):984-90. doi: 10.1016/j.neuropharm.2006.01.008. Epub 2006 Mar 20. Neuropharmacology. 2006. PMID: 16546225
SB-649915-B, a novel 5-HT1A/B autoreceptor antagonist and serotonin reuptake inhibitor, is anxiolytic and displays fast onset activity in the rat high light social interaction test.
Starr KR, Price GW, Watson JM, Atkinson PJ, Arban R, Melotto S, Dawson LA, Hagan JJ, Upton N, Duxon MS. Starr KR, et al. Among authors: hagan jj. Neuropsychopharmacology. 2007 Oct;32(10):2163-72. doi: 10.1038/sj.npp.1301341. Epub 2007 Mar 14. Neuropsychopharmacology. 2007. PMID: 17356576
Characterisation of the selective 5-HT1B receptor antagonist SB-616234-A (1-[6-(cis-3,5-dimethylpiperazin-1-yl)-2,3-dihydro-5-methoxyindol-1-yl]-1-[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methanone hydrochloride): in vivo neurochemical and behavioural evidence of anxiolytic/antidepressant activity.
Dawson LA, Hughes ZA, Starr KR, Storey JD, Bettelini L, Bacchi F, Arban R, Poffe A, Melotto S, Hagan JJ, Price GW. Dawson LA, et al. Among authors: hagan jj. Neuropharmacology. 2006 Jun;50(8):975-83. doi: 10.1016/j.neuropharm.2006.01.010. Epub 2006 Mar 31. Neuropharmacology. 2006. PMID: 16581092
137 results