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The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.
Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N. Herrera-Vaquero M, et al. Among authors: hadrovic i. Biochim Biophys Acta Mol Basis Dis. 2019 Nov 1;1865(11):165513. doi: 10.1016/j.bbadis.2019.07.007. Epub 2019 Jul 16. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31319154 Free PMC article.
Specific inhibition of the Survivin-CRM1 interaction by peptide-modified molecular tweezers.
Meiners A, Bäcker S, Hadrović I, Heid C, Beuck C, Ruiz-Blanco YB, Mieres-Perez J, Pörschke M, Grad JN, Vallet C, Hoffmann D, Bayer P, Sánchez-García E, Schrader T, Knauer SK. Meiners A, et al. Among authors: hadrovic i. Nat Commun. 2021 Mar 8;12(1):1505. doi: 10.1038/s41467-021-21753-9. Nat Commun. 2021. PMID: 33686072 Free PMC article.
Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand.
Guillory X, Hadrović I, de Vink PJ, Sowislok A, Brunsveld L, Schrader T, Ottmann C. Guillory X, et al. Among authors: hadrovic i. J Am Chem Soc. 2021 Sep 1;143(34):13495-13500. doi: 10.1021/jacs.1c07095. Epub 2021 Aug 24. J Am Chem Soc. 2021. PMID: 34427424
Potentiating Tweezer Affinity to a Protein Interface with Sequence-Defined Macromolecules on Nanoparticles.
Seiler T, Lennartz A, Klein K, Hommel K, Figueroa Bietti A, Hadrovic I, Kollenda S, Sager J, Beuck C, Chlosta E, Bayer P, Juul-Madsen K, Vorup-Jensen T, Schrader T, Epple M, Knauer SK, Hartmann L. Seiler T, et al. Among authors: hadrovic i. Biomacromolecules. 2023 Aug 14;24(8):3666-3679. doi: 10.1021/acs.biomac.3c00393. Epub 2023 Jul 28. Biomacromolecules. 2023. PMID: 37507377