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Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents.
Monk KA, Siles R, Hadimani MB, Mugabe BE, Ackley JF, Studerus SW, Edvardsen K, Trawick ML, Garner CM, Rhodes MR, Pettit GR, Pinney KG. Monk KA, et al. Among authors: hadimani mb. Bioorg Med Chem. 2006 May 1;14(9):3231-44. doi: 10.1016/j.bmc.2005.12.033. Epub 2006 Jan 25. Bioorg Med Chem. 2006. PMID: 16442292
Development of synthetic methodology suitable for the radiosynthesis of combretastatin A-1 (CA1) and its corresponding prodrug CA1P.
Shirali A, Sriram M, Hall JJ, Nguyen BL, Guddneppanavar R, Hadimani MB, Ackley JF, Siles R, Jelinek CJ, Arthasery P, Brown RC, Murrell VL, McMordie A, Sharma S, Chaplin DJ, Pinney KG. Shirali A, et al. Among authors: hadimani mb. J Nat Prod. 2009 Mar 27;72(3):414-21. doi: 10.1021/np800661r. J Nat Prod. 2009. PMID: 19161336
Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.
Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Hadimani MB, et al. J Nat Prod. 2013 Sep 27;76(9):1668-78. doi: 10.1021/np400374w. Epub 2013 Sep 9. J Nat Prod. 2013. PMID: 24016002 Free PMC article.
The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts.
Strecker TE, Odutola SO, Lopez R, Cooper MS, Tidmore JK, Charlton-Sevcik AK, Li L, MacDonough MT, Hadimani MB, Ghatak A, Liu L, Chaplin DJ, Mason RP, Pinney KG, Trawick ML. Strecker TE, et al. Among authors: hadimani mb. Cancer Lett. 2015 Dec 1;369(1):229-41. doi: 10.1016/j.canlet.2015.08.021. Epub 2015 Sep 1. Cancer Lett. 2015. PMID: 26325604 Free PMC article.
15 results