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De novo design of immunoglobulin-like domains.
Chidyausiku TM, Mendes SR, Klima JC, Nadal M, Eckhard U, Roel-Touris J, Houliston S, Guevara T, Haddox HK, Moyer A, Arrowsmith CH, Gomis-Rüth FX, Baker D, Marcos E. Chidyausiku TM, et al. Among authors: haddox hk. Nat Commun. 2022 Oct 3;13(1):5661. doi: 10.1038/s41467-022-33004-6. Nat Commun. 2022. PMID: 36192397 Free PMC article.
Large-scale design and refinement of stable proteins using sequence-only models.
Singer JM, Novotney S, Strickland D, Haddox HK, Leiby N, Rocklin GJ, Chow CM, Roy A, Bera AK, Motta FC, Cao L, Strauch EM, Chidyausiku TM, Ford A, Ho E, Zaitzeff A, Mackenzie CO, Eramian H, DiMaio F, Grigoryan G, Vaughn M, Stewart LJ, Baker D, Klavins E. Singer JM, et al. Among authors: haddox hk. PLoS One. 2022 Mar 14;17(3):e0265020. doi: 10.1371/journal.pone.0265020. eCollection 2022. PLoS One. 2022. PMID: 35286324 Free PMC article.
Perturbing the energy landscape for improved packing during computational protein design.
Maguire JB, Haddox HK, Strickland D, Halabiya SF, Coventry B, Griffin JR, Pulavarti SVSRK, Cummins M, Thieker DF, Klavins E, Szyperski T, DiMaio F, Baker D, Kuhlman B. Maguire JB, et al. Among authors: haddox hk. Proteins. 2021 Apr;89(4):436-449. doi: 10.1002/prot.26030. Epub 2020 Dec 11. Proteins. 2021. PMID: 33249652 Free PMC article.
The Role of Configurational Entropy in Miniprotein Stability.
Estrada Pabón JD, Haddox HK, Van Aken G, Pendleton IM, Eramian H, Singer JM, Schrier J. Estrada Pabón JD, et al. Among authors: haddox hk. J Phys Chem B. 2021 Apr 1;125(12):3057-3065. doi: 10.1021/acs.jpcb.0c09888. Epub 2021 Mar 19. J Phys Chem B. 2021. PMID: 33739115
15 results