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Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene.
Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K. Tanaka R, et al. Among authors: hada k. Pharmacol Res. 2023 Jan;187:106589. doi: 10.1016/j.phrs.2022.106589. Epub 2022 Nov 30. Pharmacol Res. 2023. PMID: 36462727 Free article.
Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
Hada K, Wulaer B, Nagai T, Itoh N, Sawahata M, Sobue A, Mizoguchi H, Mori D, Kushima I, Nabeshima T, Ozaki N, Yamada K. Hada K, et al. Mol Brain. 2021 Jan 22;14(1):21. doi: 10.1186/s13041-021-00735-4. Mol Brain. 2021. PMID: 33482876 Free PMC article.
ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.
Sekiguchi M, Sobue A, Kushima I, Wang C, Arioka Y, Kato H, Kodama A, Kubo H, Ito N, Sawahata M, Hada K, Ikeda R, Shinno M, Mizukoshi C, Tsujimura K, Yoshimi A, Ishizuka K, Takasaki Y, Kimura H, Xing J, Yu Y, Yamamoto M, Okada T, Shishido E, Inada T, Nakatochi M, Takano T, Kuroda K, Amano M, Aleksic B, Yamomoto T, Sakuma T, Aida T, Tanaka K, Hashimoto R, Arai M, Ikeda M, Iwata N, Shimamura T, Nagai T, Nabeshima T, Kaibuchi K, Yamada K, Mori D, Ozaki N. Sekiguchi M, et al. Among authors: hada k. Transl Psychiatry. 2020 Jul 22;10(1):247. doi: 10.1038/s41398-020-00917-z. Transl Psychiatry. 2020. PMID: 32699248 Free PMC article.
Shati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus.
Wulaer B, Kunisawa K, Hada K, Jaya Suento W, Kubota H, Iida T, Kosuge A, Nagai T, Yamada K, Nitta A, Yamamoto Y, Saito K, Mouri A, Nabeshima T. Wulaer B, et al. Among authors: hada k. J Neurochem. 2021 May;157(3):642-655. doi: 10.1111/jnc.15022. Epub 2020 May 8. J Neurochem. 2021. PMID: 32275776 Free article.
Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.
Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Yoshimi A, et al. Among authors: hada k. Transl Psychiatry. 2019 Apr 22;9(1):126. doi: 10.1038/s41398-019-0461-2. Transl Psychiatry. 2019. PMID: 31011151 Free PMC article.
Author Correction: Proteomic analysis of lymphoblastoid cell lines from schizophrenic patients.
Yoshimi A, Yamada S, Kunimoto S, Aleksic B, Hirakawa A, Ohashi M, Matsumoto Y, Hada K, Itoh N, Arioka Y, Kimura H, Kushima I, Nakamura Y, Shiino T, Mori D, Tanaka S, Hamada S, Noda Y, Nagai T, Yamada K, Ozaki N. Yoshimi A, et al. Among authors: hada k. Transl Psychiatry. 2019 May 3;9(1):146. doi: 10.1038/s41398-019-0479-5. Transl Psychiatry. 2019. PMID: 31053702 Free PMC article.
Acyclic retinoid targets platelet-derived growth factor signaling in the prevention of hepatic fibrosis and hepatocellular carcinoma development.
Okada H, Honda M, Campbell JS, Sakai Y, Yamashita T, Takebuchi Y, Hada K, Shirasaki T, Takabatake R, Nakamura M, Sunagozaka H, Tanaka T, Fausto N, Kaneko S. Okada H, et al. Among authors: hada k. Cancer Res. 2012 Sep 1;72(17):4459-71. doi: 10.1158/0008-5472.CAN-12-0028. Epub 2012 May 31. Cancer Res. 2012. PMID: 22651928
71 results