Hackos DH - Search Results

1

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy.

Khan Z, Jung M, Crow M, Mohindra R, Maiya V, Kaminker JS, Hackos DH, Chandler GS, McCarthy MI, Bhangale T. Khan Z, et al. Among authors: hackos dh. Genome Med. 2023 Jun 21;15(1):45. doi: 10.1186/s13073-023-01193-4. Genome Med. 2023. PMID: 37344884 Free PMC article.

2

Nav1.7 is essential for nociceptor action potentials in the mouse in a manner independent of endogenous opioids.

Deng L, Dourado M, Reese RM, Huang K, Shields SD, Stark KL, Maksymetz J, Lin H, Kaminker JS, Jung M, Foreman O, Tao J, Ngu H, Joseph V, Roose-Girma M, Tam L, Lardell S, Orrhult LS, Karila P, Allard J, Hackos DH. Deng L, et al. Among authors: hackos dh. Neuron. 2023 Sep 6;111(17):2642-2659.e13. doi: 10.1016/j.neuron.2023.05.024. Epub 2023 Jun 22. Neuron. 2023. PMID: 37352856 Free article.

3

Context-specific stress causes compartmentalized SARM1 activation and local degeneration in cortical neurons.

Hinz FI, Villegas CLM, Roberts JT, Yao H, Gaddam S, Delwig A, Green SA, Fredrickson C, Adrian M, Asuncion RR, Cheung TK, Hayne M, Hackos DH, Rose CM, Richmond D, Hoogenraad CC. Hinz FI, et al. Among authors: hackos dh. J Neurosci. 2024 May 1:e2424232024. doi: 10.1523/JNEUROSCI.2424-23.2024. Online ahead of print. J Neurosci. 2024. PMID: 38692735

4

Toxigenic Clostridium perfringens isolated from at-risk pediatric inflammatory bowel disease patients.

Kuo J, Uzunovic J, Jacobson A, Dourado M, Gierke S, Rajendram M, Keilberg D, Mar J, Stekol E, Curry J, Verstraete S, Lund J, Liang Y, Tamburini FB, Omattage NS, Masureel M, Rutherford ST, Hackos DH, Tan MW, Byrd AL, Keir ME, Skippington E, Storek KM. Kuo J, et al. Among authors: hackos dh. J Crohns Colitis. 2024 Jan 24:jjae016. doi: 10.1093/ecco-jcc/jjae016. Online ahead of print. J Crohns Colitis. 2024. PMID: 38267224

5

Challenges of profiling motor neuron transcriptomes from human spinal cord.

Gautier O, Blum JA, Maksymetz J, Chen D, Schweingruber C, Mei I, Hermann A, Hackos DH, Hedlund E, Ravits J, Gitler AD. Gautier O, et al. Among authors: hackos dh. Neuron. 2023 Dec 6;111(23):3739-3741. doi: 10.1016/j.neuron.2023.10.035. Neuron. 2023. PMID: 38061330 No abstract available.

6

Discovery of TRPA1 Antagonist GDC-6599: Derisking Preclinical Toxicity and Aldehyde Oxidase Metabolism with a Potential First-in-Class Therapy for Respiratory Disease.

Terrett JA, Ly JQ, Katavolos P, Hasselgren C, Laing S, Zhong F, Villemure E, Déry M, Larouche-Gauthier R, Chen H, Shore DG, Lee WP, Suto E, Johnson K, Brooks M, Stablein A, Beaumier F, Constantineau-Forget L, Grand-Maître C, Lépissier L, Ciblat S, Sturino C, Chen Y, Hu B, Elstrott J, Gandham V, Joseph V, Booler H, Cain G, Chou C, Fullerton A, Lepherd M, Stainton S, Torres E, Urban K, Yu L, Zhong Y, Bao L, Chou KJ, Lin J, Zhang W, La H, Liu L, Mulder T, Chen J, Chernov-Rogan T, Johnson AR, Hackos DH, Leahey R, Shields SD, Balestrini A, Riol-Blanco L, Safina BS, Volgraf M, Magnuson S, Kakiuchi-Kiyota S. Terrett JA, et al. Among authors: hackos dh. J Med Chem. 2024 Mar 14;67(5):3287-3306. doi: 10.1021/acs.jmedchem.3c02121. Epub 2024 Mar 3. J Med Chem. 2024. PMID: 38431835

7

Cryo-EM reveals an unprecedented binding site for Na_V1.7 inhibitors enabling rational design of potent hybrid inhibitors.

Kschonsak M, Jao CC, Arthur CP, Rohou AL, Bergeron P, Ortwine DF, McKerrall SJ, Hackos DH, Deng L, Chen J, Li T, Dragovich PS, Volgraf M, Wright MR, Payandeh J, Ciferri C, Tellis JC. Kschonsak M, et al. Among authors: hackos dh. Elife. 2023 Mar 28;12:e84151. doi: 10.7554/eLife.84151. Elife. 2023. PMID: 36975198 Free PMC article.

8

Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function.

Jung M, Dourado M, Maksymetz J, Jacobson A, Laufer BI, Baca M, Foreman O, Hackos DH, Riol-Blanco L, Kaminker JS. Jung M, et al. Among authors: hackos dh. Nat Commun. 2023 Jan 23;14(1):366. doi: 10.1038/s41467-023-36014-0. Nat Commun. 2023. PMID: 36690629 Free PMC article.

9

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

Terrett JA, Chen H, Shore DG, Villemure E, Larouche-Gauthier R, Déry M, Beaumier F, Constantineau-Forget L, Grand-Maître C, Lépissier L, Ciblat S, Sturino C, Chen Y, Hu B, Lu A, Wang Y, Cridland AP, Ward SI, Hackos DH, Reese RM, Shields SD, Chen J, Balestrini A, Riol-Blanco L, Lee WP, Liu J, Suto E, Wu X, Zhang J, Ly JQ, La H, Johnson K, Baumgardner M, Chou KJ, Rohou A, Rougé L, Safina BS, Magnuson S, Volgraf M. Terrett JA, et al. Among authors: hackos dh. J Med Chem. 2021 Apr 8;64(7):3843-3869. doi: 10.1021/acs.jmedchem.0c02023. Epub 2021 Mar 22. J Med Chem. 2021. PMID: 33749283

10

Discovery of Acyl-sulfonamide Na_v1.7 Inhibitors GDC-0276 and GDC-0310.

Safina BS, McKerrall SJ, Sun S, Chen CA, Chowdhury S, Jia Q, Li J, Zenova AY, Andrez JC, Bankar G, Bergeron P, Chang JH, Chang E, Chen J, Dean R, Decker SM, DiPasquale A, Focken T, Hemeon I, Khakh K, Kim A, Kwan R, Lindgren A, Lin S, Maher J, Mezeyova J, Misner D, Nelkenbrecher K, Pang J, Reese R, Shields SD, Sojo L, Sheng T, Verschoof H, Waldbrook M, Wilson MS, Xie Z, Young C, Zabka TS, Hackos DH, Ortwine DF, White AD, Johnson JP Jr, Robinette CL, Dehnhardt CM, Cohen CJ, Sutherlin DP. Safina BS, et al. Among authors: hackos dh. J Med Chem. 2021 Mar 25;64(6):2953-2966. doi: 10.1021/acs.jmedchem.1c00049. Epub 2021 Mar 8. J Med Chem. 2021. PMID: 33682420

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