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Synthesis of sulfated phenyl 2-acetamido-2-deoxy-D-galactopyranosides. 4-O-Sulfated phenyl 2-acetamido-2-deoxy-beta-D-galactopyranoside is a competitive acceptor that decreases sulfation of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase.
Sawada T, Fujii S, Nakano H, Ohtake S, Kimata K, Habuchi O. Sawada T, et al. Among authors: habuchi o. Carbohydr Res. 2005 Sep 5;340(12):1983-96. doi: 10.1016/j.carres.2005.06.010. Carbohydr Res. 2005. PMID: 16024005
Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.
Ohtake-Niimi S, Kondo S, Ito T, Kakehi S, Ohta T, Habuchi H, Kimata K, Habuchi O. Ohtake-Niimi S, et al. Among authors: habuchi o, habuchi h. J Biol Chem. 2010 Jul 2;285(27):20793-805. doi: 10.1074/jbc.M109.084749. Epub 2010 May 3. J Biol Chem. 2010. PMID: 20439988 Free PMC article.
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