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Staphylococcus aureus toxin LukSF dissociates from its membrane receptor target to enable renewed ligand sequestration.
Haapasalo K, Wollman AJM, de Haas CJC, van Kessel KPM, van Strijp JAG, Leake MC. Haapasalo K, et al. FASEB J. 2019 Mar;33(3):3807-3824. doi: 10.1096/fj.201801910R. Epub 2018 Dec 3. FASEB J. 2019. PMID: 30509126 Free PMC article.
This effect may free mobile receptors to amplify hyperinflammatory reactions in early stages of microbial infections and have implications for several other similar bicomponent toxins and the design of new antibiotics.-Haapasalo, K., Wollman, A. J. M., de Haas, C. J …
This effect may free mobile receptors to amplify hyperinflammatory reactions in early stages of microbial infections and have implications f …
Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles.
Haapasalo K, van Kessel K, Nissilä E, Metso J, Johansson T, Miettinen S, Varjosalo M, Kirveskari J, Kuusela P, Chroni A, Jauhiainen M, van Strijp J, Jokiranta TS. Haapasalo K, et al. J Biol Chem. 2015 Nov 27;290(48):28977-87. doi: 10.1074/jbc.M115.669226. Epub 2015 Oct 14. J Biol Chem. 2015. PMID: 26468283 Free PMC article.
Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages.
Nissilä E, Hakala P, Leskinen K, Roig A, Syed S, Van Kessel KPM, Metso J, De Haas CJC, Saavalainen P, Meri S, Chroni A, Van Strijp JAG, Öörni K, Jauhiainen M, Jokiranta TS, Haapasalo K. Nissilä E, et al. Among authors: haapasalo k. Front Immunol. 2018 Nov 21;9:2701. doi: 10.3389/fimmu.2018.02701. eCollection 2018. Front Immunol. 2018. PMID: 30519244 Free PMC article.
Reduced binding of apoE4 to complement factor H promotes amyloid-β oligomerization and neuroinflammation.
Chernyaeva L, Ratti G, Teirilä L, Fudo S, Rankka U, Pelkonen A, Korhonen P, Leskinen K, Keskitalo S, Salokas K, Gkolfinopoulou C, Crompton KE, Javanainen M, Happonen L, Varjosalo M, Malm T, Leinonen V, Chroni A, Saavalainen P, Meri S, Kajander T, Wollman AJ, Nissilä E, Haapasalo K. Chernyaeva L, et al. Among authors: haapasalo k. EMBO Rep. 2023 Jul 5;24(7):e56467. doi: 10.15252/embr.202256467. Epub 2023 May 8. EMBO Rep. 2023. PMID: 37155564 Free PMC article.
Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood.
Syed S, Hakala P, Singh AK, Lapatto HAK, King SJ, Meri S, Jokiranta TS, Haapasalo K. Syed S, et al. Among authors: haapasalo k. Front Cell Infect Microbiol. 2019 Jun 26;9:218. doi: 10.3389/fcimb.2019.00218. eCollection 2019. Front Cell Infect Microbiol. 2019. PMID: 31297339 Free PMC article.
Y402H polymorphism of complement factor H affects binding affinity to C-reactive protein.
Laine M, Jarva H, Seitsonen S, Haapasalo K, Lehtinen MJ, Lindeman N, Anderson DH, Johnson PT, Järvelä I, Jokiranta TS, Hageman GS, Immonen I, Meri S. Laine M, et al. Among authors: haapasalo k. J Immunol. 2007 Mar 15;178(6):3831-6. doi: 10.4049/jimmunol.178.6.3831. J Immunol. 2007. PMID: 17339482 Free PMC article. Clinical Trial.
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