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2004 1
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Page 1
Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells.
Jehle J, Ficker E, Wan X, Deschenes I, Kisselbach J, Wiedmann F, Staudacher I, Schmidt C, Schweizer PA, Becker R, Katus HA, Thomas D. Jehle J, et al. Br J Pharmacol. 2013 Mar;168(5):1215-29. doi: 10.1111/bph.12002. Br J Pharmacol. 2013. PMID: 23061993 Free PMC article.
Carvedilol targets human K2P 3.1 (TASK1) K+ leak channels.
Staudacher K, Staudacher I, Ficker E, Seyler C, Gierten J, Kisselbach J, Rahm AK, Trappe K, Schweizer PA, Becker R, Katus HA, Thomas D. Staudacher K, et al. Br J Pharmacol. 2011 Jul;163(5):1099-110. doi: 10.1111/j.1476-5381.2011.01319.x. Br J Pharmacol. 2011. PMID: 21410455 Free PMC article.
hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.
Staudacher I, Wang L, Wan X, Obers S, Wenzel W, Tristram F, Koschny R, Staudacher K, Kisselbach J, Koelsch P, Schweizer PA, Katus HA, Ficker E, Thomas D. Staudacher I, et al. Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):119-39. doi: 10.1007/s00210-010-0583-9. Epub 2010 Dec 1. Naunyn Schmiedebergs Arch Pharmacol. 2011. PMID: 21120454
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine.
Obers S, Staudacher I, Ficker E, Dennis A, Koschny R, Erdal H, Bloehs R, Kisselbach J, Karle CA, Schweizer PA, Katus HA, Thomas D. Obers S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):385-400. doi: 10.1007/s00210-010-0496-7. Epub 2010 Mar 13. Naunyn Schmiedebergs Arch Pharmacol. 2010. PMID: 20229012 Free article.
Pentamidine-induced long QT syndrome and block of hERG trafficking.
Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennis AT, Wible BA, Brown AM, Kang J, Chen XL, Sawamura K, Reynolds W, Rampe D. Kuryshev YA, et al. J Pharmacol Exp Ther. 2005 Jan;312(1):316-23. doi: 10.1124/jpet.104.073692. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340016