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Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice.
Am J Respir Cell Mol Biol. 2012 Apr;46(4):461-9. doi: 10.1165/rcmb.2011-0234OC. Epub 2011 Nov 3.
Am J Respir Cell Mol Biol. 2012.
PMID: 22052879
Free PMC article.
Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation.
Makena PS, Gorantla VK, Ghosh MC, Bezawada L, Balazs L, Luellen C, Parthasarathi K, Waters CM, Sinclair SE.
Makena PS, et al.
J Appl Physiol (1985). 2011 Nov;111(5):1467-76. doi: 10.1152/japplphysiol.00539.2011. Epub 2011 Jul 28.
J Appl Physiol (1985). 2011.
PMID: 21799126
Free PMC article.
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Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes.
Makena PS, Luellen CL, Balazs L, Ghosh MC, Parthasarathi K, Waters CM, Sinclair SE.
Makena PS, et al.
Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L711-9. doi: 10.1152/ajplung.00072.2010. Epub 2010 Sep 10.
Am J Physiol Lung Cell Mol Physiol. 2010.
PMID: 20833778
Free PMC article.
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Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse.
Sinclair SE, Chi E, Lin HI, Altemeier WA.
Sinclair SE, et al.
J Crit Care. 2009 Jun;24(2):206-11. doi: 10.1016/j.jcrc.2008.04.005. Epub 2008 Jul 21.
J Crit Care. 2009.
PMID: 19327294
Free PMC article.
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