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Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. He W, et al. Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655024 Free PMC article.
Synthesis of [15 N]-cholamine bromide hydrobromide.
Szeto J, Lemoine R, Nguyen R, Olson LL, Tanga MJ. Szeto J, et al. J Labelled Comp Radiopharm. 2018 Apr;61(4):391-394. doi: 10.1002/jlcr.3598. Epub 2018 Mar 30. J Labelled Comp Radiopharm. 2018. PMID: 29278650 Free PMC article.
Dimethyl Itaconate Is Not Metabolized into Itaconate Intracellularly.
ElAzzouny M, Tom CT, Evans CR, Olson LL, Tanga MJ, Gallagher KA, Martin BR, Burant CF. ElAzzouny M, et al. J Biol Chem. 2017 Mar 24;292(12):4766-4769. doi: 10.1074/jbc.C117.775270. Epub 2017 Feb 10. J Biol Chem. 2017. PMID: 28188288 Free PMC article.