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A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness.
Sego TJ, Aponte-Serrano JO, Ferrari Gianlupi J, Heaps SR, Breithaupt K, Brusch L, Crawshaw J, Osborne JM, Quardokus EM, Plemper RK, Glazier JA. Sego TJ, et al. PLoS Comput Biol. 2020 Dec 21;16(12):e1008451. doi: 10.1371/journal.pcbi.1008451. eCollection 2020 Dec. PLoS Comput Biol. 2020. PMID: 33347439 Free PMC article.
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase.
Cox RM, Sourimant J, Toots M, Yoon JJ, Ikegame S, Govindarajan M, Watkinson RE, Thibault P, Makhsous N, Lin MJ, Marengo JR, Sticher Z, Kolykhalov AA, Natchus MG, Greninger AL, Lee B, Plemper RK. Cox RM, et al. Nat Microbiol. 2020 Oct;5(10):1232-1246. doi: 10.1038/s41564-020-0752-7. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661315 Free PMC article.
A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness: A multiscale model of viral infection in epithelial tissues.
Sego TJ, Aponte-Serrano JO, Gianlupi JF, Heaps SR, Breithaupt K, Brusch L, Crawshaw J, Osborne JM, Quardokus EM, Plemper RK, Glazier JA. Sego TJ, et al. bioRxiv [Preprint]. 2020 Sep 26:2020.04.27.064139. doi: 10.1101/2020.04.27.064139. bioRxiv. 2020. PMID: 32511367 Free PMC article. Updated. Preprint.
Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus.
Pribut N, Kaiser TM, Wilson RJ, Jecs E, Dentmon ZW, Pelly SC, Sharma S, Bartsch PW 3rd, Burger PB, Hwang SS, Le T, Sourimant J, Yoon JJ, Plemper RK, Liotta DC. Pribut N, et al. ACS Infect Dis. 2020 May 8;6(5):922-929. doi: 10.1021/acsinfecdis.9b00524. Epub 2020 Apr 20. ACS Infect Dis. 2020. PMID: 32275393 Free PMC article.
Measles Resurgence and Drug Development.
Plemper RK. Plemper RK. Curr Opin Virol. 2020 Apr;41:8-17. doi: 10.1016/j.coviro.2020.02.007. Epub 2020 Apr 1. Curr Opin Virol. 2020. PMID: 32247280 Free PMC article. Review.
Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia.
Toots M, Yoon JJ, Cox RM, Hart M, Sticher ZM, Makhsous N, Plesker R, Barrena AH, Reddy PG, Mitchell DG, Shean RC, Bluemling GR, Kolykhalov AA, Greninger AL, Natchus MG, Painter GR, Plemper RK. Toots M, et al. Sci Transl Med. 2019 Oct 23;11(515):eaax5866. doi: 10.1126/scitranslmed.aax5866. Sci Transl Med. 2019. PMID: 31645453 Free PMC article.
35 results