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Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-d]pyrimidine Inhibitor Targeting Mitochondrial and Cytosolic One-Carbon Metabolism.
Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Frühauf J, Wallace-Povirk A, O'Connor C, Hou Z, Kim S, Hüttemann M, Gangjee A, Matherly LH. Dekhne AS, et al. Among authors: huttemann m. Mol Pharmacol. 2020 Jan;97(1):9-22. doi: 10.1124/mol.119.117937. Epub 2019 Nov 9. Mol Pharmacol. 2020. PMID: 31707355 Free PMC article.
De novo sequencing and construction of a unique antibody for the recognition of alternative conformations of cytochrome c in cells.
Tomasina F, Martínez J, Zeida A, Chiribao ML, Demicheli V, Correa A, Quijano C, Castro L, Carnahan RH, Vinson P, Goff M, Cooper T, McDonald WH, Castellana N, Hannibal L, Morse PT, Wan J, Hüttemann M, Jemmerson R, Piacenza L, Radi R. Tomasina F, et al. Among authors: huttemann m. Proc Natl Acad Sci U S A. 2022 Nov 22;119(47):e2213432119. doi: 10.1073/pnas.2213432119. Epub 2022 Nov 15. Proc Natl Acad Sci U S A. 2022. PMID: 36378644 Free PMC article.
Tissue-specific regulation of cytochrome c by post-translational modifications: respiration, the mitochondrial membrane potential, ROS, and apoptosis.
Kalpage HA, Bazylianska V, Recanati MA, Fite A, Liu J, Wan J, Mantena N, Malek MH, Podgorski I, Heath EI, Vaishnav A, Edwards BF, Grossman LI, Sanderson TH, Lee I, Hüttemann M. Kalpage HA, et al. Among authors: huttemann m. FASEB J. 2019 Feb;33(2):1540-1553. doi: 10.1096/fj.201801417R. Epub 2018 Sep 17. FASEB J. 2019. PMID: 30222078 Free PMC article. Review.
-Kalpage, H. A., Bazylianska, V., Recanati, M. A., Fite, A., Liu, J., Wan, J., Mantena, N., Malek, M. H., Podgorski, I., Heath, E. I., Vaishnav, A., Edwards, B. F., Grossman, L. I., Sanderson, T. H., Lee, I., Huttemann, M. Tissue-specific regulation of …
-Kalpage, H. A., Bazylianska, V., Recanati, M. A., Fite, A., Liu, J., Wan, J., Mantena, N., Malek, M. H., Podgorski, I., Heath …
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy.
Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, Kushner J, Kim S, Hüttemann M, Polin L, Rabinowitz JD, Li J, Hou Z, Dann CE 3rd, Gangjee A, Matherly LH. Dekhne AS, et al. Among authors: huttemann m. Mol Cancer Ther. 2019 Oct;18(10):1787-1799. doi: 10.1158/1535-7163.MCT-19-0037. Epub 2019 Jul 9. Mol Cancer Ther. 2019. PMID: 31289137 Free PMC article.
Serine-47 phosphorylation of cytochrome c in the mammalian brain regulates cytochrome c oxidase and caspase-3 activity.
Kalpage HA, Vaishnav A, Liu J, Varughese A, Wan J, Turner AA, Ji Q, Zurek MP, Kapralov AA, Kagan VE, Brunzelle JS, Recanati MA, Grossman LI, Sanderson TH, Lee I, Salomon AR, Edwards BFP, Hüttemann M. Kalpage HA, et al. Among authors: huttemann m. FASEB J. 2019 Dec;33(12):13503-13514. doi: 10.1096/fj.201901120R. Epub 2019 Sep 28. FASEB J. 2019. PMID: 31570002 Free PMC article.
., Liu, J., Varughese, A., Wan, J., Turner, A. A., Ji, Q., Zurek, M. P., Kapralov, A. A., Kagan, V. E., Brunzelle, J. S., Recanati, M....I., Sanderson, T. H., Lee, I., Salomon, A. R., Edwards, B. F. P, Huttemann, M. Serine-47 phosphorylation of cytochr …
., Liu, J., Varughese, A., Wan, J., Turner, A. A., Ji, Q., Zurek, M. P., Kapralov, A. A., Kagan, V. E., Brunzelle, J. S., Recanati, …
Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation.
Wan J, Kalpage HA, Vaishnav A, Liu J, Lee I, Mahapatra G, Turner AA, Zurek MP, Ji Q, Moraes CT, Recanati MA, Grossman LI, Salomon AR, Edwards BFP, Hüttemann M. Wan J, et al. Among authors: huttemann m. Sci Rep. 2019 Nov 1;9(1):15815. doi: 10.1038/s41598-019-52101-z. Sci Rep. 2019. PMID: 31676852 Free PMC article.
Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis.
Kalpage HA, Wan J, Morse PT, Zurek MP, Turner AA, Khobeir A, Yazdi N, Hakim L, Liu J, Vaishnav A, Sanderson TH, Recanati MA, Grossman LI, Lee I, Edwards BFP, Hüttemann M. Kalpage HA, et al. Among authors: huttemann m. Int J Biochem Cell Biol. 2020 Apr;121:105704. doi: 10.1016/j.biocel.2020.105704. Epub 2020 Feb 2. Int J Biochem Cell Biol. 2020. PMID: 32023432 Free PMC article.
Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation.
Liu F, Kalpage HA, Wang D, Edwards H, Hüttemann M, Ma J, Su Y, Carter J, Li X, Polin L, Kushner J, Dzinic SH, White K, Wang G, Taub JW, Ge Y. Liu F, et al. Among authors: huttemann m. Cancers (Basel). 2020 Aug 24;12(9):2400. doi: 10.3390/cancers12092400. Cancers (Basel). 2020. PMID: 32847115 Free PMC article.
150 results