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The adipokine sFRP4 induces insulin resistance and lipogenesis in the liver.
Hörbelt T, Knebel B, Fahlbusch P, Barbosa D, de Wiza DH, Van de Velde F, Van Nieuwenhove Y, Lapauw B, Thoresen GH, Al-Hasani H, Müller-Wieland D, Ouwens DM, Kotzka J. Hörbelt T, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2671-2684. doi: 10.1016/j.bbadis.2019.07.008. Epub 2019 Jul 20. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31336149 Free article.
Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver.
Jelenik T, Kaul K, Séquaris G, Flögel U, Phielix E, Kotzka J, Knebel B, Fahlbusch P, Hörbelt T, Lehr S, Reinbeck AL, Müller-Wieland D, Esposito I, Shulman GI, Szendroedi J, Roden M. Jelenik T, et al. Among authors: horbelt t. Diabetes. 2017 Aug;66(8):2241-2253. doi: 10.2337/db16-1147. Epub 2017 May 10. Diabetes. 2017. PMID: 28490610 Free PMC article.
The novel adipokine WISP1 associates with insulin resistance and impairs insulin action in human myotubes and mouse hepatocytes.
Hörbelt T, Tacke C, Markova M, Herzfeld de Wiza D, Van de Velde F, Bekaert M, Van Nieuwenhove Y, Hornemann S, Rödiger M, Seebeck N, Friedl E, Jonas W, Thoresen GH, Kuss O, Rosenthal A, Lange V, Pfeiffer AFH, Schürmann A, Lapauw B, Rudovich N, Pivovarova O, Ouwens DM. Hörbelt T, et al. Diabetologia. 2018 Sep;61(9):2054-2065. doi: 10.1007/s00125-018-4636-9. Epub 2018 May 12. Diabetologia. 2018. PMID: 29754289
Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity.
Bekaert M, Ouwens DM, Hörbelt T, Van de Velde F, Fahlbusch P, Herzfeld de Wiza D, Van Nieuwenhove Y, Calders P, Praet M, Hoorens A, Geerts A, Verhelst X, Kaufman JM, Lapauw B. Bekaert M, et al. Among authors: horbelt t. Obesity (Silver Spring). 2016 Dec;24(12):2544-2552. doi: 10.1002/oby.21674. Epub 2016 Oct 21. Obesity (Silver Spring). 2016. PMID: 27768254 Free article.
CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.
Göddeke S, Knebel B, Fahlbusch P, Hörbelt T, Poschmann G, van de Velde F, Benninghoff T, Al-Hasani H, Jacob S, Van Nieuwenhove Y, Lapauw B, Lehr S, Ouwens DM, Kotzka J. Göddeke S, et al. Among authors: horbelt t. Int J Obes (Lond). 2018 Jun;42(5):1039-1050. doi: 10.1038/s41366-018-0022-4. Epub 2018 Feb 21. Int J Obes (Lond). 2018. PMID: 29467502
Assessment of circulating Wnt1 inducible signalling pathway protein 1 (WISP-1)/CCN4 as a novel biomarker of obesity.
Tacke C, Aleksandrova K, Rehfeldt M, Murahovschi V, Markova M, Kemper M, Hornemann S, Kaiser U, Honig C, Gerbracht C, Kabisch S, Hörbelt T, Ouwens DM, Weickert MO, Boeing H, Pfeiffer AFH, Pivovarova O, Rudovich N. Tacke C, et al. Among authors: horbelt t. J Cell Commun Signal. 2018 Sep;12(3):539-548. doi: 10.1007/s12079-017-0427-1. Epub 2017 Nov 11. J Cell Commun Signal. 2018. PMID: 29129025 Free PMC article.
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