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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes.
Combot Y, Salo VT, Chadeuf G, Hölttä M, Ven K, Pulli I, Ducheix S, Pecqueur C, Renoult O, Lak B, Li S, Karhinen L, Belevich I, Le May C, Rieusset J, Le Lay S, Croyal M, Tayeb KS, Vihinen H, Jokitalo E, Törnquist K, Vigouroux C, Cariou B, Magré J, Larhlimi A, Ikonen E, Prieur X. Combot Y, et al. Among authors: holtta m. Cell Rep. 2022 Jan 11;38(2):110213. doi: 10.1016/j.celrep.2021.110213. Cell Rep. 2022. PMID: 35021082 Free article.
Lipid Metabolic Reprogramming Extends beyond Histologic Tumor Demarcations in Operable Human Pancreatic Cancer.
Pirhonen J, Szkalisity Á, Hagström J, Kim Y, Migh E, Kovács M, Hölttä M, Peränen J, Seppänen H, Haglund C, Gil J, Rezeli M, Malm J, Horvath P, Markó-Varga G, Puolakkainen P, Ikonen E. Pirhonen J, et al. Among authors: holtta m. Cancer Res. 2022 Nov 2;82(21):3932-3949. doi: 10.1158/0008-5472.CAN-22-0396. Cancer Res. 2022. PMID: 36054547
The Combination of Vascular Endothelial Growth Factor A (VEGF-A) and Fibroblast Growth Factor 1 (FGF1) Modified mRNA Improves Wound Healing in Diabetic Mice: An Ex Vivo and In Vivo Investigation.
Tejedor S, Wågberg M, Correia C, Åvall K, Hölttä M, Hultin L, Lerche M, Davies N, Bergenhem N, Snijder A, Marlow T, Dönnes P, Fritsche-Danielson R, Synnergren J, Jennbacken K, Hansson K. Tejedor S, et al. Among authors: holtta m. Cells. 2024 Feb 27;13(5):414. doi: 10.3390/cells13050414. Cells. 2024. PMID: 38474378 Free PMC article.
Injectable Biodegradable Silica Depot for Controlled Subcutaneous Delivery of Antisense Oligonucleotides with beyond Monthly Administration.
McGowan A, Gennemark P, Akieh-Pirkanniemi M, Wirman L, Davies N, Elebring M, Tivesten A, Strimfors M, Hölttä M, Söderberg M, Berntsson V, Balas D, Koskinen M, Leino L, Abrahmsén-Alami S. McGowan A, et al. Among authors: holtta m. Mol Pharm. 2024 Jan 1;21(1):143-151. doi: 10.1021/acs.molpharmaceut.3c00663. Epub 2023 Dec 21. Mol Pharm. 2024. PMID: 38126776
An oral antisense oligonucleotide for PCSK9 inhibition.
Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Among authors: holtta m. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578
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