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Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.
Chapellier M, Peña-Martínez P, Ramakrishnan R, Eriksson M, Talkhoncheh MS, Orsmark-Pietras C, Lilljebjörn H, Högberg C, Hagström-Andersson A, Fioretos T, Larsson J, Järås M. Chapellier M, et al. Among authors: hogberg c. Haematologica. 2019 Oct;104(10):2006-2016. doi: 10.3324/haematol.2018.192062. Epub 2019 Feb 28. Haematologica. 2019. PMID: 30819903 Free PMC article.
CXCR4 Signaling Has a CXCL12-Independent Essential Role in Murine MLL-AF9-Driven Acute Myeloid Leukemia.
Ramakrishnan R, Peña-Martínez P, Agarwal P, Rodriguez-Zabala M, Chapellier M, Högberg C, Eriksson M, Yudovich D, Shah M, Ehinger M, Nilsson B, Larsson J, Hagström-Andersson A, Ebert BL, Bhatia R, Järås M. Ramakrishnan R, et al. Among authors: hogberg c. Cell Rep. 2020 May 26;31(8):107684. doi: 10.1016/j.celrep.2020.107684. Cell Rep. 2020. PMID: 32460032 Free PMC article.
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.
Ågerstam H, Karlsson C, Hansen N, Sandén C, Askmyr M, von Palffy S, Högberg C, Rissler M, Wunderlich M, Juliusson G, Richter J, Sjöström K, Bhatia R, Mulloy JC, Järås M, Fioretos T. Ågerstam H, et al. Among authors: hogberg c. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10786-91. doi: 10.1073/pnas.1422749112. Epub 2015 Aug 10. Proc Natl Acad Sci U S A. 2015. PMID: 26261316 Free PMC article.
Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells.
Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M. Eriksson M, et al. Among authors: hogberg c. Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24. Blood Adv. 2017. PMID: 29296851 Free PMC article.
Clonal competition within complex evolutionary hierarchies shapes AML over time.
Sandén C, Lilljebjörn H, Orsmark Pietras C, Henningsson R, Saba KH, Landberg N, Thorsson H, von Palffy S, Peña-Martinez P, Högberg C, Rissler M, Gisselsson D, Lazarevic V, Juliusson G, Ågerstam H, Fioretos T. Sandén C, et al. Among authors: hogberg c. Nat Commun. 2020 Feb 5;11(1):579. doi: 10.1038/s41467-019-14106-0. Nat Commun. 2020. PMID: 32024830 Free PMC article.
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.
Ågerstam H, Hansen N, von Palffy S, Sandén C, Reckzeh K, Karlsson C, Lilljebjörn H, Landberg N, Askmyr M, Högberg C, Rissler M, Porkka K, Wadenvik H, Mustjoki S, Richter J, Järås M, Fioretos T. Ågerstam H, et al. Among authors: hogberg c. Blood. 2016 Dec 8;128(23):2683-2693. doi: 10.1182/blood-2015-11-679985. Epub 2016 Sep 12. Blood. 2016. PMID: 27621309 Free article.
Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.
Askmyr M, Ågerstam H, Lilljebjörn H, Hansen N, Karlsson C, von Palffy S, Landberg N, Högberg C, Lassen C, Rissler M, Richter J, Ehinger M, Järås M, Fioretos T. Askmyr M, et al. Among authors: hogberg c. Blood Cancer J. 2014 Dec 12;4(12):e269. doi: 10.1038/bcj.2014.89. Blood Cancer J. 2014. PMID: 25501026 Free PMC article.
37 results