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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K, Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Färkkilä M, Garbrielsen ME, Ghanbari M, Hagen K, Häppölä P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kähönen M, Kristoffersen ES, Kurth T, Lehtimäki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx BWJH, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widén E, van Dijk KW; International Headache Genetics Consortium; HUNT All-in Headache; Danish Blood Donor Study Genomic Cohort; Aromaa A, Belin AC, Freilinger T, Ikram MA, Järvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefánsson H, Stefansson K, van den Maagdenberg AMJM, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M. Hautakangas H, et al. Among authors: happola p. Nat Genet. 2022 Feb;54(2):152-160. doi: 10.1038/s41588-021-00990-0. Epub 2022 Feb 3. Nat Genet. 2022. PMID: 35115687 Free PMC article.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC); Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A. Gormley P, et al. Among authors: happola p. Neuron. 2018 May 16;98(4):743-753.e4. doi: 10.1016/j.neuron.2018.04.014. Epub 2018 May 3. Neuron. 2018. PMID: 29731251 Free PMC article.
Polygenic risk provides biological validity for the ICHD-3 criteria among Finnish migraine families.
Häppölä P, Gormley P, Nuottamo ME, Artto V, Sumelahti ML, Nissilä M, Keski-Säntti P, Ilmavirta M, Kaunisto MA, Hämäläinen EI, Ripatti S, Pirinen M, Wessman M, Palotie A, Kallela M; International Headache Genetics Consortium (IHGC). Häppölä P, et al. Cephalalgia. 2022 Apr;42(4-5):345-356. doi: 10.1177/03331024211045651. Epub 2021 Oct 14. Cephalalgia. 2022. PMID: 34648375 Free PMC article.
NCOR2 is a novel candidate gene for migraine-epilepsy phenotype.
Nuottamo ME, Häppölä P, Artto V, Hautakangas H, Pirinen M, Hiekkalinna T, Ellonen P, Lepistö M, Hämäläinen E; International Headache Genetics Consortium (IHGC), FinnGenConsortium; Siren A, Lehesjoki AE, Kallela M, Palotie A, Kaunisto MA, Wessman M. Nuottamo ME, et al. Among authors: happola p. Cephalalgia. 2022 Jun;42(7):631-644. doi: 10.1177/03331024211068065. Epub 2022 Feb 15. Cephalalgia. 2022. PMID: 35166138
The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.
Hiekkala ME, Vuola P, Artto V, Häppölä P, Häppölä E, Vepsäläinen S, Cuenca-León E, Lal D, Gormley P, Hämäläinen E, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Harno H, Havanka H, Keski-Säntti P, Färkkilä M, Palotie A, Wessman M, Kaunisto MA, Kallela M. Hiekkala ME, et al. Among authors: happola e, happola p. Cephalalgia. 2018 Oct;38(12):1849-1863. doi: 10.1177/0333102418761041. Epub 2018 Feb 27. Cephalalgia. 2018. PMID: 29486580
A data-driven medication score predicts 10-year mortality among aging adults.
Häppölä P, Havulinna AS, Tasa T, Mars NJ, Perola M, Kallela M, Milani L, Koskinen S, Salomaa V, Neale BM, Palotie A, Daly M, Ripatti S. Häppölä P, et al. Sci Rep. 2020 Sep 25;10(1):15760. doi: 10.1038/s41598-020-72045-z. Sci Rep. 2020. PMID: 32978407 Free PMC article.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M; 23andMe Research Team; International Headache Genetics Consortium (IHGC); Runz H, Daly MJ, Neale BM, Ripatti S, Kallela M, Wessman M, Palotie A. Gormley P, et al. Among authors: happola p. Neuron. 2018 Sep 5;99(5):1098. doi: 10.1016/j.neuron.2018.08.029. Neuron. 2018. PMID: 30189203 Free article. No abstract available.
Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.
Lokki AI, Daly E, Triebwasser M, Kurki MI, Roberson EDO, Häppölä P, Auro K, Perola M, Heinonen S, Kajantie E, Kere J, Kivinen K, Pouta A, Salmon JE, Meri S, Daly M, Atkinson JP, Laivuori H. Lokki AI, et al. Among authors: happola p. Hypertension. 2017 Aug;70(2):365-371. doi: 10.1161/HYPERTENSIONAHA.117.09406. Epub 2017 Jun 26. Hypertension. 2017. PMID: 28652462 Free PMC article.
Evidence of survival bias in the association between APOE-ϵ4 and age of ischemic stroke onset.
von Berg J, McArdle PF, Häppölä P, Haessler J, Kooperberg C, Lemmens R, Pezzini A, Thijs V; SiGN, FinnGen, Women’s Health Initiative; Pulit SL, Kittner SJ, Mitchell BD, de Ridder J, van der Laan SW. von Berg J, et al. Among authors: happola p. medRxiv [Preprint]. 2023 Dec 1:2023.12.01.23294385. doi: 10.1101/2023.12.01.23294385. medRxiv. 2023. PMID: 38076909 Free PMC article. Preprint.
13 results