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In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts.
Imhof D, Anghel N, Winzer P, Balmer V, Ramseier J, Hänggeli K, Choi R, Hulverson MA, Whitman GR, Arnold SLM, Ojo KK, Van Voorhis WC, Doggett JS, Ortega-Mora LM, Hemphill A. Imhof D, et al. Int J Parasitol Drugs Drug Resist. 2021 Aug;16:90-101. doi: 10.1016/j.ijpddr.2021.05.001. Epub 2021 May 18. Int J Parasitol Drugs Drug Resist. 2021. PMID: 34030110 Free PMC article.
Immunization with a Multivalent Listeria monocytogenes Vaccine Leads to a Strong Reduction in Vertical Transmission and Cerebral Parasite Burden in Pregnant and Non-Pregnant Mice Infected with Neospora caninum.
Imhof D, Pownall W, Hänggeli KPA, Monney C, Román LR, Ortega-Mora LM, Forterre F, Oevermann A, Hemphill A. Imhof D, et al. Among authors: hanggeli kpa. Vaccines (Basel). 2023 Jan 11;11(1):156. doi: 10.3390/vaccines11010156. Vaccines (Basel). 2023. PMID: 36680001 Free PMC article.
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice.
Schlange C, Müller J, Imhof D, Hänggeli KPA, Boubaker G, Ortega-Mora LM, Wong HN, Haynes RK, Van Voorhis WC, Hemphill A. Schlange C, et al. Among authors: hanggeli kpa. Exp Parasitol. 2023 Dec;255:108655. doi: 10.1016/j.exppara.2023.108655. Epub 2023 Nov 18. Exp Parasitol. 2023. PMID: 37981259 Free article.
In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii.
Boubaker G, Bernal A, Vigneswaran A, Imhof D, de Sousa MCF, Hänggeli KPA, Haudenschild N, Furrer J, Păunescu E, Desiatkina O, Hemphill A. Boubaker G, et al. Among authors: hanggeli kpa. Int J Parasitol Drugs Drug Resist. 2024 Apr 27;25:100544. doi: 10.1016/j.ijpddr.2024.100544. Online ahead of print. Int J Parasitol Drugs Drug Resist. 2024. PMID: 38703737 Free article.