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Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people.
Derhovanessian E, Maier AB, Hähnel K, Zelba H, de Craen AJ, Roelofs H, Slagboom EP, Westendorp RG, Pawelec G. Derhovanessian E, et al. Among authors: hahnel k. Age (Dordr). 2013 Aug;35(4):1387-99. doi: 10.1007/s11357-012-9425-7. Epub 2012 Jun 4. Age (Dordr). 2013. PMID: 22661297 Free PMC article.
Hallmark features of immunosenescence are absent in familial longevity.
Derhovanessian E, Maier AB, Beck R, Jahn G, Hähnel K, Slagboom PE, de Craen AJ, Westendorp RG, Pawelec G. Derhovanessian E, et al. Among authors: hahnel k. J Immunol. 2010 Oct 15;185(8):4618-24. doi: 10.4049/jimmunol.1001629. Epub 2010 Sep 20. J Immunol. 2010. PMID: 20855876
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