Gygi SP - Search Results

1

Proteostasis and lysosomal quality control deficits in Alzheimer's disease neurons.

Chou CC, Vest R, Prado MA, Wilson-Grady J, Paulo JA, Shibuya Y, Moran-Losada P, Lee TT, Luo J, Gygi SP, Kelly JW, Finley D, Wernig M, Wyss-Coray T, Frydman J. Chou CC, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Mar 27:2023.03.27.534444. doi: 10.1101/2023.03.27.534444. bioRxiv. 2023. PMID: 37034684 Free PMC article. Preprint.

2

Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis.

Elia L, Herting B, Alijagic A, Buselli C, Wong L, Morrison G, Prado MA, Paulo JA, Gygi SP, Finley D, Finkbeiner S. Elia L, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Jan 20:2023.01.18.524611. doi: 10.1101/2023.01.18.524611. bioRxiv. 2023. PMID: 36712069 Free PMC article. Preprint.

3

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation.

Mitchell W, Goeminne LJE, Tyshkovskiy A, Zhang S, Chen JY, Paulo JA, Pierce KA, Choy AH, Clish CB, Gygi SP, Gladyshev VN. Mitchell W, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Nov 27:2023.06.30.546730. doi: 10.1101/2023.06.30.546730. bioRxiv. 2023. PMID: 37425825 Free PMC article. Updated. Preprint.

4

Synaptic Activity Causes Minute-scale Changes in BAF Complex Composition and Function.

Gourisankar S, Wenderski W, Paulo JA, Kim SH, Roepke K, Ellis C, Gygi SP, Crabtree GR. Gourisankar S, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Oct 14:2023.10.13.562244. doi: 10.1101/2023.10.13.562244. bioRxiv. 2023. PMID: 37873481 Free PMC article. Preprint.

5

The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.

Chen H, Ferguson CJ, Mitchell DC, Titus A, Paulo JA, Hwang A, Lin TH, Yano H, Gu W, Song SK, Yuede CM, Gygi SP, Bonni A, Kim AH. Chen H, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2024 Jan 13:2023.10.24.563880. doi: 10.1101/2023.10.24.563880. bioRxiv. 2024. PMID: 37961719 Free PMC article. Preprint.

6

UBXN1 maintains ER proteostasis and represses UPR activation by modulating translation.

Ahlstedt BA, Ganji R, Mukkavalli S, Paulo JA, Gygi SP, Raman M. Ahlstedt BA, et al. Among authors: gygi sp. EMBO Rep. 2024 Feb;25(2):672-703. doi: 10.1038/s44319-023-00027-z. Epub 2024 Jan 2. EMBO Rep. 2024. PMID: 38177917 Free PMC article.

7

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation.

Li H, Ji Z, Paulo JA, Gygi SP, Rapoport TA. Li H, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Dec 20:2023.12.20.572403. doi: 10.1101/2023.12.20.572403. bioRxiv. 2023. PMID: 38187576 Free PMC article. Updated. Preprint.

8

Substrate identification and specificity profiling of deubiquitylases against endogenously-generated ubiquitin-protein conjugates.

Rossio V, Paulo JA, Liu X, Gygi SP, King RW. Rossio V, et al. Among authors: gygi sp. bioRxiv [Preprint]. 2023 Dec 20:2023.12.20.572581. doi: 10.1101/2023.12.20.572581. bioRxiv. 2023. PMID: 38187689 Free PMC article. Preprint.

9

ALS-related p97 R155H mutation disrupts lysophagy in iPSC-derived motor neurons.

Klickstein JA, Johnson MA, Antonoudiou P, Maguire J, Paulo JA, Gygi SP, Weihl C, Raman M. Klickstein JA, et al. Among authors: gygi sp. Stem Cell Reports. 2024 Mar 12;19(3):366-382. doi: 10.1016/j.stemcr.2024.01.002. Epub 2024 Feb 8. Stem Cell Reports. 2024. PMID: 38335961 Free PMC article.

10

Bidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation.

Li H, Ji Z, Paulo JA, Gygi SP, Rapoport TA. Li H, et al. Among authors: gygi sp. Mol Cell. 2024 Apr 4;84(7):1290-1303.e7. doi: 10.1016/j.molcel.2024.01.029. Epub 2024 Feb 23. Mol Cell. 2024. PMID: 38401542 Free article.

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