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Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis.
Nakamizo S, Dutertre CA, Khalilnezhad A, Zhang XM, Lim S, Lum J, Koh G, Foong C, Yong PJA, Tan KJ, Sato R, Tomari K, Yvan-Charvet L, He H, Guttman-Yassky E, Malleret B, Shibuya R, Iwata M, Janela B, Goto T, Lucinda TS, Tang MBY, Theng C, Julia V, Hacini-Rachinel F, Kabashima K, Ginhoux F. Nakamizo S, et al. J Exp Med. 2021 Sep 6;218(9):e20202345. doi: 10.1084/jem.20202345. Epub 2021 Jul 19. J Exp Med. 2021. PMID: 34279540 Free PMC article.
Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin.
Natsuaki Y, Egawa G, Nakamizo S, Ono S, Hanakawa S, Okada T, Kusuba N, Otsuka A, Kitoh A, Honda T, Nakajima S, Tsuchiya S, Sugimoto Y, Ishii KJ, Tsutsui H, Yagita H, Iwakura Y, Kubo M, Ng Lg, Hashimoto T, Fuentes J, Guttman-Yassky E, Miyachi Y, Kabashima K. Natsuaki Y, et al. Nat Immunol. 2014 Nov;15(11):1064-9. doi: 10.1038/ni.2992. Epub 2014 Sep 21. Nat Immunol. 2014. PMID: 25240383 Free article.
The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization.
Noda S, Suárez-Fariñas M, Ungar B, Kim SJ, de Guzman Strong C, Xu H, Peng X, Estrada YD, Nakajima S, Honda T, Shin JU, Lee H, Krueger JG, Lee KH, Kabashima K, Guttman-Yassky E. Noda S, et al. J Allergy Clin Immunol. 2015 Nov;136(5):1254-64. doi: 10.1016/j.jaci.2015.08.015. Epub 2015 Oct 1. J Allergy Clin Immunol. 2015. PMID: 26428954
Major differences between human atopic dermatitis and murine models, as determined by using global transcriptomic profiling.
Ewald DA, Noda S, Oliva M, Litman T, Nakajima S, Li X, Xu H, Workman CT, Scheipers P, Svitacheva N, Labuda T, Krueger JG, Suárez-Fariñas M, Kabashima K, Guttman-Yassky E. Ewald DA, et al. J Allergy Clin Immunol. 2017 Feb;139(2):562-571. doi: 10.1016/j.jaci.2016.08.029. Epub 2016 Oct 1. J Allergy Clin Immunol. 2017. PMID: 27702671
Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.
Brunner PM, Silverberg JI, Guttman-Yassky E, Paller AS, Kabashima K, Amagai M, Luger TA, Deleuran M, Werfel T, Eyerich K, Stingl G; Councilors of the International Eczema Council. Brunner PM, et al. J Invest Dermatol. 2017 Jan;137(1):18-25. doi: 10.1016/j.jid.2016.08.022. Epub 2016 Oct 20. J Invest Dermatol. 2017. PMID: 27771048 Free article. Review.
Dust mite induces multiple polar T cell axes in human skin.
Malik K, Ungar B, Garcet S, Dutt R, Dickstein D, Zheng X, Xu H, Estrada YD, Suárez-Fariñas M, Shemer A, Krueger JG, Guttman-Yassky E. Malik K, et al. Clin Exp Allergy. 2017 Dec;47(12):1648-1660. doi: 10.1111/cea.13040. Epub 2017 Nov 6. Clin Exp Allergy. 2017. PMID: 28977706
Serum from Asian patients with atopic dermatitis is characterized by TH2/TH22 activation, which is highly correlated with nonlesional skin measures.
Wen HC, Czarnowicki T, Noda S, Malik K, Pavel AB, Nakajima S, Honda T, Shin JU, Lee H, Chou M, Estrada Y, Zheng X, Xu H, Krueger JG, Lee KH, Kabashima K, Guttman-Yassky E. Wen HC, et al. J Allergy Clin Immunol. 2018 Jul;142(1):324-328.e11. doi: 10.1016/j.jaci.2018.02.047. Epub 2018 Apr 11. J Allergy Clin Immunol. 2018. PMID: 29653116 No abstract available.
JAK Inhibitors for Atopic Dermatitis: An Update.
He H, Guttman-Yassky E. He H, et al. Am J Clin Dermatol. 2019 Apr;20(2):181-192. doi: 10.1007/s40257-018-0413-2. Am J Clin Dermatol. 2019. PMID: 30536048 Review.
384 results