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Synthesis, conformational analysis, and cytotoxicity of conformationally constrained aplidine and tamandarin A analogues incorporating a spirolactam beta-turn mimetic.
Gutiérrez-Rodríguez M, Martín-Martínez M, García-López MT, Herranz R, Cuevas F, Polanco C, Rodríguez-Campos I, Manzanares I, Cárdenas F, Feliz M, Lloyd-Williams P, Giralt E. Gutiérrez-Rodríguez M, et al. J Med Chem. 2004 Nov 4;47(23):5700-12. doi: 10.1021/jm040788m. J Med Chem. 2004. PMID: 15509169
New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
Alonso De Diego SA, Gutiérrez-Rodríguez M, Pérez de Vega MJ, Casabona D, Cativiela C, González-Muñiz R, Herranz R, Cenarruzabeitia E, Frechilla D, Del Río J, Jimeno ML, García-López MT. Alonso De Diego SA, et al. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6. doi: 10.1016/j.bmcl.2005.11.040. Bioorg Med Chem Lett. 2006. PMID: 16321525
The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.
Alonso De Diego SA, Gutiérrez-Rodríguez M, Pérez de Vega MJ, González-Muñiz R, Herranz R, Martín-Martínez M, Cenarruzabeitia E, Frechilla D, Del Río J, Jimeno ML, García-López MT. Alonso De Diego SA, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3396-400. doi: 10.1016/j.bmcl.2006.04.033. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16650992
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease.
Naranjo JR, Zhang H, Villar D, González P, Dopazo XM, Morón-Oset J, Higueras E, Oliveros JC, Arrabal MD, Prieto A, Cercós P, González T, De la Cruz A, Casado-Vela J, Rábano A, Valenzuela C, Gutierrez-Rodriguez M, Li JY, Mellström B. Naranjo JR, et al. J Clin Invest. 2016 Feb;126(2):627-38. doi: 10.1172/JCI82670. Epub 2016 Jan 11. J Clin Invest. 2016. PMID: 26752648 Free PMC article.
68 results