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Deamidated Human Triosephosphate Isomerase is a Promising Druggable Target.
Enríquez-Flores S, Flores-López LA, García-Torres I, de la Mora-de la Mora I, Cabrera N, Gutiérrez-Castrellón P, Martínez-Pérez Y, López-Velázquez G. Enríquez-Flores S, et al. Biomolecules. 2020 Jul 15;10(7):1050. doi: 10.3390/biom10071050. Biomolecules. 2020. PMID: 32679775 Free PMC article.
Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia.
Reyes-Vivas H, de la Mora-de la Mora I, Castillo-Villanueva A, Yépez-Mulia L, Hernández-Alcántara G, Figueroa-Salazar R, García-Torres I, Gómez-Manzo S, Méndez ST, Vanoye-Carlo A, Marcial-Quino J, Torres-Arroyo A, Oria-Hernández J, Gutiérrez-Castrellón P, Enríquez-Flores S, López-Velázquez G. Reyes-Vivas H, et al. Antimicrob Agents Chemother. 2014 Dec;58(12):7072-82. doi: 10.1128/AAC.02900-14. Epub 2014 Sep 15. Antimicrob Agents Chemother. 2014. PMID: 25223993 Free PMC article.
Proton pump inhibitors drastically modify triosephosphate isomerase from Giardia lamblia at functional and structural levels, providing molecular leads in the design of new antigiardiasic drugs.
García-Torres I, de la Mora-de la Mora I, Marcial-Quino J, Gómez-Manzo S, Vanoye-Carlo A, Navarrete-Vázquez G, Colín-Lozano B, Gutiérrez-Castrellón P, Sierra-Palacios E, López-Velázquez G, Enríquez-Flores S. García-Torres I, et al. Biochim Biophys Acta. 2016 Jan;1860(1 Pt A):97-107. doi: 10.1016/j.bbagen.2015.10.021. Epub 2015 Oct 28. Biochim Biophys Acta. 2016. PMID: 26518348
On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug.
López-Velázquez G, Fernández-Lainez C, de la Mora-de la Mora JI, Caudillo de la Portilla D, Reynoso-Robles R, González-Maciel A, Ridaura C, García-Torres I, Gutiérrez-Castrellón P, Olivos-García A, Flores-López LA, Enríquez-Flores S. López-Velázquez G, et al. Sci Rep. 2019 Jun 20;9(1):8922. doi: 10.1038/s41598-019-45529-w. Sci Rep. 2019. PMID: 31222100 Free PMC article.
Naturally occurring deamidated triosephosphate isomerase is a promising target for cell-selective therapy in cancer.
Enríquez-Flores S, Flores-López LA, De la Mora-De la Mora I, García-Torres I, Gracia-Mora I, Gutiérrez-Castrellón P, Fernández-Lainez C, Martínez-Pérez Y, Olaya-Vargas A, de Vos P, López-Velázquez G. Enríquez-Flores S, et al. Among authors: gutierrez castrellon p. Sci Rep. 2022 Mar 7;12(1):4028. doi: 10.1038/s41598-022-08051-0. Sci Rep. 2022. PMID: 35256749 Free PMC article.
Determining the molecular mechanism of inactivation by chemical modification of triosephosphate isomerase from the human parasite Giardia lamblia: a study for antiparasitic drug design.
Enríquez-Flores S, Rodríguez-Romero A, Hernández-Alcántara G, Oria-Hernández J, Gutiérrez-Castrellón P, Pérez-Hernández G, de la Mora-de la Mora I, Castillo-Villanueva A, García-Torres I, Méndez ST, Gómez-Manzo S, Torres-Arroyo A, López-Velázquez G, Reyes-Vivas H. Enríquez-Flores S, et al. Proteins. 2011 Sep;79(9):2711-24. doi: 10.1002/prot.23100. Epub 2011 Jul 22. Proteins. 2011. PMID: 21786322
Multilevel Approach for the Treatment of Giardiasis by Targeting Arginine Deiminase.
Fernández-Lainez C, de la Mora-de la Mora I, García-Torres I, Enríquez-Flores S, Flores-López LA, Gutiérrez-Castrellón P, Yépez-Mulia L, Matadamas-Martínez F, de Vos P, López-Velázquez G. Fernández-Lainez C, et al. Int J Mol Sci. 2021 Aug 31;22(17):9491. doi: 10.3390/ijms22179491. Int J Mol Sci. 2021. PMID: 34502400 Free PMC article.
Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences.
de la Mora-de la Mora JI, Enríquez-Flores S, Fernández-Lainez C, Gutiérrez-Castrellón P, Olivos-García A, González-Canto A, Hernández R, Luján HD, García-Torres I, López-Velázquez G. de la Mora-de la Mora JI, et al. Mol Biochem Parasitol. 2019 Mar;228:16-26. doi: 10.1016/j.molbiopara.2019.01.001. Epub 2019 Jan 15. Mol Biochem Parasitol. 2019. PMID: 30658179
The Giardial Arginine Deiminase Participates in Giardia-Host Immunomodulation in a Structure-Dependent Fashion via Toll-like Receptors.
Fernández-Lainez C, de la Mora-de la Mora I, Enríquez-Flores S, García-Torres I, Flores-López LA, Gutiérrez-Castrellón P, de Vos P, López-Velázquez G. Fernández-Lainez C, et al. Among authors: gutierrez castrellon p. Int J Mol Sci. 2022 Sep 30;23(19):11552. doi: 10.3390/ijms231911552. Int J Mol Sci. 2022. PMID: 36232855 Free PMC article.
77 results