Guthrie DA - Search Results

1

Illuminating the norepinephrine transporter: fluorescent probes based on nisoxetine and talopram.

Camacho-Hernandez GA, Casiraghi A, Rudin D, Luethi D, Ku TC, Guthrie DA, Straniero V, Valoti E, Schütz GJ, Sitte HH, Newman AH. Camacho-Hernandez GA, et al. Among authors: guthrie da. RSC Med Chem. 2021 Jun 9;12(7):1174-1186. doi: 10.1039/d1md00072a. eCollection 2021 Jul 21. RSC Med Chem. 2021. PMID: 34355183 Free PMC article.

2

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH. Zou MF, et al. Among authors: guthrie da. J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11. J Med Chem. 2017. PMID: 29227643 Free PMC article.

3

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

Guthrie DA, Klein Herenbrink C, Lycas MD, Ku T, Bonifazi A, DeVree BT, Mathiasen S, Javitch JA, Grimm JB, Lavis L, Gether U, Newman AH. Guthrie DA, et al. ACS Chem Neurosci. 2020 Oct 21;11(20):3288-3300. doi: 10.1021/acschemneuro.0c00397. Epub 2020 Oct 1. ACS Chem Neurosci. 2020. PMID: 32926777 Free PMC article.

4

Tropane-Based Ibogaine Analog Rescues Folding-Deficient Serotonin and Dopamine Transporters.

Bhat S, Guthrie DA, Kasture A, El-Kasaby A, Cao J, Bonifazi A, Ku T, Giancola JB, Hummel T, Freissmuth M, Newman AH. Bhat S, et al. Among authors: guthrie da. ACS Pharmacol Transl Sci. 2020 Aug 28;4(2):503-516. doi: 10.1021/acsptsci.0c00102. eCollection 2021 Apr 9. ACS Pharmacol Transl Sci. 2020. PMID: 33860180 Free PMC article.

5

Targeting of dopamine transporter to filopodia requires an outward-facing conformation of the transporter.

Ma S, Cheng MH, Guthrie DA, Newman AH, Bahar I, Sorkin A. Ma S, et al. Among authors: guthrie da. Sci Rep. 2017 Jul 14;7(1):5399. doi: 10.1038/s41598-017-05637-x. Sci Rep. 2017. PMID: 28710426 Free PMC article.

6

Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity.

Lycas MD, Ejdrup AL, Sørensen AT, Haahr NO, Jørgensen SH, Guthrie DA, Støier JF, Werner C, Newman AH, Sauer M, Herborg F, Gether U. Lycas MD, et al. Among authors: guthrie da. Cell Rep. 2022 Sep 27;40(13):111431. doi: 10.1016/j.celrep.2022.111431. Cell Rep. 2022. PMID: 36170827 Free PMC article.

7

Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.

Yano H, Bonifazi A, Xu M, Guthrie DA, Schneck SN, Abramyan AM, Fant AD, Hong WC, Newman AH, Shi L. Yano H, et al. Among authors: guthrie da. Neuropharmacology. 2018 May 1;133:264-275. doi: 10.1016/j.neuropharm.2018.01.042. Epub 2018 Jan 31. Neuropharmacology. 2018. PMID: 29407216 Free PMC article.

8

Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties.

Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH. Silm K, et al. Among authors: guthrie da. Neuron. 2019 May 22;102(4):786-800.e5. doi: 10.1016/j.neuron.2019.03.031. Epub 2019 Apr 16. Neuron. 2019. PMID: 31003725 Free PMC article.

9

"Catch-and-release" of HNO with pyrazolones.

Guthrie DA, Ho A, Takahashi CG, Collins A, Morris M, Toscano JP. Guthrie DA, et al. J Org Chem. 2015 Feb 6;80(3):1338-48. doi: 10.1021/jo502330w. Epub 2015 Jan 28. J Org Chem. 2015. PMID: 25594416

10

Curtailing the hydroxylaminobarbituric acid-hydantoin rearrangement to favor HNO generation.

Guthrie DA, Nourian S, Takahashi CG, Toscano JP. Guthrie DA, et al. J Org Chem. 2015 Feb 6;80(3):1349-56. doi: 10.1021/jo5023316. Epub 2015 Jan 28. J Org Chem. 2015. PMID: 25585151

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