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Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.
Nat Cancer. 2022 Feb;3(2):156-172. doi: 10.1038/s43018-022-00331-y. Epub 2022 Feb 28.
Nat Cancer. 2022.
PMID: 35228749
Free PMC article.
PFKFB3 Inhibition Sensitizes DNA Crosslinking Chemotherapies by Suppressing Fanconi Anemia Repair.
Ninou AH, Lehto J, Chioureas D, Stigsdotter H, Schelzig K, Åkerlund E, Gudoityte G, Joneborg U, Carlson J, Jonkers J, Seashore-Ludlow B, Gustafsson NMS.
Ninou AH, et al. Among authors: gustafsson nms.
Cancers (Basel). 2021 Jul 18;13(14):3604. doi: 10.3390/cancers13143604.
Cancers (Basel). 2021.
PMID: 34298817
Free PMC article.
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The γ-tubulin meshwork assists in the recruitment of PCNA to chromatin in mammalian cells.
Corvaisier M, Zhou J, Malycheva D, Cornella N, Chioureas D, Gustafsson NMS, Rosselló CA, Ayora S, Li T, Ekström-Holka K, Jirström K, Lindström L, Alvarado-Kristensson M.
Corvaisier M, et al. Among authors: gustafsson nms.
Commun Biol. 2021 Jun 22;4(1):767. doi: 10.1038/s42003-021-02280-1.
Commun Biol. 2021.
PMID: 34158617
Free PMC article.
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Targeting CX3CR1 Suppresses the Fanconi Anemia DNA Repair Pathway and Synergizes with Platinum.
Lehto J, Huguet Ninou A, Chioureas D, Jonkers J, Gustafsson NMS.
Lehto J, et al. Among authors: gustafsson nms.
Cancers (Basel). 2021 Mar 22;13(6):1442. doi: 10.3390/cancers13061442.
Cancers (Basel). 2021.
PMID: 33810010
Free PMC article.
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Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Gustafsson NMS, Färnegårdh K, Bonagas N, Ninou AH, Groth P, Wiita E, Jönsson M, Hallberg K, Lehto J, Pennisi R, Martinsson J, Norström C, Hollers J, Schultz J, Andersson M, Markova N, Marttila P, Kim B, Norin M, Olin T, Helleday T.
Gustafsson NMS, et al.
Nat Commun. 2018 Sep 24;9(1):3872. doi: 10.1038/s41467-018-06287-x.
Nat Commun. 2018.
PMID: 30250201
Free PMC article.
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Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor.
Gustafsson R, Jemth AS, Gustafsson NM, Färnegårdh K, Loseva O, Wiita E, Bonagas N, Dahllund L, Llona-Minguez S, Häggblad M, Henriksson M, Andersson Y, Homan E, Helleday T, Stenmark P.
Gustafsson R, et al.
Cancer Res. 2017 Feb 15;77(4):937-948. doi: 10.1158/0008-5472.CAN-16-1476. Epub 2016 Nov 29.
Cancer Res. 2017.
PMID: 27899380
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