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Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control.
Gurzeler LA, Link M, Ibig Y, Schmidt I, Galuba O, Schoenbett J, Gasser-Didierlaurant C, Parker CN, Mao X, Bitsch F, Schirle M, Couttet P, Sigoillot F, Ziegelmüller J, Uldry AC, Teodorowicz W, Schmiedeberg N, Mühlemann O, Reinhardt J. Gurzeler LA, et al. Cell Rep. 2023 Sep 26;42(9):113056. doi: 10.1016/j.celrep.2023.113056. Epub 2023 Aug 30. Cell Rep. 2023. PMID: 37651229 Free article.
Human NMD ensues independently of stable ribosome stalling.
Karousis ED, Gurzeler LA, Annibaldis G, Dreos R, Mühlemann O. Karousis ED, et al. Among authors: gurzeler la. Nat Commun. 2020 Aug 17;11(1):4134. doi: 10.1038/s41467-020-17974-z. Nat Commun. 2020. PMID: 32807779 Free PMC article.
SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation.
Schubert K, Karousis ED, Jomaa A, Scaiola A, Echeverria B, Gurzeler LA, Leibundgut M, Thiel V, Mühlemann O, Ban N. Schubert K, et al. Among authors: gurzeler la. Nat Struct Mol Biol. 2020 Oct;27(10):959-966. doi: 10.1038/s41594-020-0511-8. Epub 2020 Sep 9. Nat Struct Mol Biol. 2020. PMID: 32908316
Drug-induced eRF1 degradation promotes readthrough and reveals a new branch of ribosome quality control.
Gurzeler LA, Link M, Ibig Y, Schmidt I, Galuba O, Schoenbett J, Gasser-Didierlaurant C, Parker CN, Mao X, Bitsch F, Schirle M, Couttet P, Sigoillot F, Ziegelmüller J, Uldry AC, Teodorowicz W, Schmiedeberg N, Mühlemann O, Reinhardt J. Gurzeler LA, et al. Cell Rep. 2023 Sep 26;42(9):113159. doi: 10.1016/j.celrep.2023.113159. Epub 2023 Sep 13. Cell Rep. 2023. PMID: 37708027 Free article. No abstract available.