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Dual Targeting of Chromatin Stability By The Curaxin CBL0137 and Histone Deacetylase Inhibitor Panobinostat Shows Significant Preclinical Efficacy in Neuroblastoma.
Xiao L, Somers K, Murray J, Pandher R, Karsa M, Ronca E, Bongers A, Terry R, Ehteda A, Gamble LD, Issaeva N, Leonova KI, O'Connor A, Mayoh C, Venkat P, Quek H, Brand J, Kusuma FK, Pettitt JA, Mosmann E, Kearns A, Eden G, Alfred S, Allan S, Zhai L, Kamili A, Gifford AJ, Carter DR, Henderson MJ, Fletcher JI, Marshall G, Johnstone RW, Cesare AJ, Ziegler DS, Gudkov AV, Gurova KV, Norris MD, Haber M. Xiao L, et al. Among authors: gurova kv. Clin Cancer Res. 2021 Aug 1;27(15):4338-4352. doi: 10.1158/1078-0432.CCR-20-2357. Epub 2021 May 16. Clin Cancer Res. 2021. PMID: 33994371 Free PMC article.
p53 determines multidrug sensitivity of childhood neuroblastoma.
Xue C, Haber M, Flemming C, Marshall GM, Lock RB, MacKenzie KL, Gurova KV, Norris MD, Gudkov AV. Xue C, et al. Among authors: gurova kv. Cancer Res. 2007 Nov 1;67(21):10351-60. doi: 10.1158/0008-5472.CAN-06-4345. Cancer Res. 2007. PMID: 17974978
Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
Burkhart CA, Watt F, Murray J, Pajic M, Prokvolit A, Xue C, Flemming C, Smith J, Purmal A, Isachenko N, Komarov PG, Gurova KV, Sartorelli AC, Marshall GM, Norris MD, Gudkov AV, Haber M. Burkhart CA, et al. Among authors: gurova kv. Cancer Res. 2009 Aug 15;69(16):6573-80. doi: 10.1158/0008-5472.CAN-09-1075. Epub 2009 Aug 4. Cancer Res. 2009. PMID: 19654298 Free PMC article.
Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications.
Neznanov N, Gorbachev AV, Neznanova L, Komarov AP, Gurova KV, Gasparian AV, Banerjee AK, Almasan A, Fairchild RL, Gudkov AV. Neznanov N, et al. Among authors: gurova kv. Cell Cycle. 2009 Dec;8(23):3960-70. doi: 10.4161/cc.8.23.10179. Epub 2009 Dec 25. Cell Cycle. 2009. PMID: 19901558 Free PMC article.
Inflammation and p53: A Tale of Two Stresses.
Gudkov AV, Gurova KV, Komarova EA. Gudkov AV, et al. Among authors: gurova kv. Genes Cancer. 2011 Apr;2(4):503-16. doi: 10.1177/1947601911409747. Genes Cancer. 2011. PMID: 21779518 Free PMC article.
Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.
Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV. Gasparian AV, et al. Among authors: gurova kv. Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530. Sci Transl Med. 2011. PMID: 21832239 Free PMC article.
71 results