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Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins.
Chang HW, Valieva ME, Safina A, Chereji RV, Wang J, Kulaeva OI, Morozov AV, Kirpichnikov MP, Feofanov AV, Gurova KV, Studitsky VM. Chang HW, et al. Among authors: gurova kv. Sci Adv. 2018 Nov 7;4(11):eaav2131. doi: 10.1126/sciadv.aav2131. eCollection 2018 Nov. Sci Adv. 2018. PMID: 30417101 Free PMC article.
Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT.
Gasparian AV, Burkhart CA, Purmal AA, Brodsky L, Pal M, Saranadasa M, Bosykh DA, Commane M, Guryanova OA, Pal S, Safina A, Sviridov S, Koman IE, Veith J, Komar AA, Gudkov AV, Gurova KV. Gasparian AV, et al. Among authors: gurova kv. Sci Transl Med. 2011 Aug 10;3(95):95ra74. doi: 10.1126/scitranslmed.3002530. Sci Transl Med. 2011. PMID: 21832239 Free PMC article.
Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.
Koman IE, Commane M, Paszkiewicz G, Hoonjan B, Pal S, Safina A, Toshkov I, Purmal AA, Wang D, Liu S, Morrison C, Gudkov AV, Gurova KV. Koman IE, et al. Among authors: gurova kv. Cancer Prev Res (Phila). 2012 Aug;5(8):1025-35. doi: 10.1158/1940-6207.CAPR-11-0529. Epub 2012 Jun 11. Cancer Prev Res (Phila). 2012. PMID: 22689915
Facilitates chromatin transcription complex is an "accelerator" of tumor transformation and potential marker and target of aggressive cancers.
Garcia H, Miecznikowski JC, Safina A, Commane M, Ruusulehto A, Kilpinen S, Leach RW, Attwood K, Li Y, Degan S, Omilian AR, Guryanova O, Papantonopoulou O, Wang J, Buck M, Liu S, Morrison C, Gurova KV. Garcia H, et al. Among authors: gurova kv. Cell Rep. 2013 Jul 11;4(1):159-73. doi: 10.1016/j.celrep.2013.06.013. Epub 2013 Jul 3. Cell Rep. 2013. PMID: 23831030 Free PMC article.
FACT is a sensor of DNA torsional stress in eukaryotic cells.
Safina A, Cheney P, Pal M, Brodsky L, Ivanov A, Kirsanov K, Lesovaya E, Naberezhnov D, Nesher E, Koman I, Wang D, Wang J, Yakubovskaya M, Winkler D, Gurova K. Safina A, et al. Nucleic Acids Res. 2017 Feb 28;45(4):1925-1945. doi: 10.1093/nar/gkw1366. Nucleic Acids Res. 2017. PMID: 28082391 Free PMC article.
71 results