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A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.
Hayek SS, Koh KH, Grams ME, Wei C, Ko YA, Li J, Samelko B, Lee H, Dande RR, Lee HW, Hahm E, Peev V, Tracy M, Tardi NJ, Gupta V, Altintas MM, Garborcauskas G, Stojanovic N, Winkler CA, Lipkowitz MS, Tin A, Inker LA, Levey AS, Zeier M, Freedman BI, Kopp JB, Skorecki K, Coresh J, Quyyumi AA, Sever S, Reiser J. Hayek SS, et al. Among authors: gupta v. Nat Med. 2017 Aug;23(8):945-953. doi: 10.1038/nm.4362. Epub 2017 Jun 26. Nat Med. 2017. PMID: 28650456 Free PMC article.
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Hahm E, et al. Among authors: gupta v. Nat Med. 2017 Jan;23(1):100-106. doi: 10.1038/nm.4242. Epub 2016 Dec 12. Nat Med. 2017. PMID: 27941791 Free PMC article.
Modification of kidney barrier function by the urokinase receptor.
Wei C, Möller CC, Altintas MM, Li J, Schwarz K, Zacchigna S, Xie L, Henger A, Schmid H, Rastaldi MP, Cowan P, Kretzler M, Parrilla R, Bendayan M, Gupta V, Nikolic B, Kalluri R, Carmeliet P, Mundel P, Reiser J. Wei C, et al. Among authors: gupta v. Nat Med. 2008 Jan;14(1):55-63. doi: 10.1038/nm1696. Epub 2007 Dec 16. Nat Med. 2008. PMID: 18084301
Stop that podocyte!
Gupta V, Reiser J. Gupta V, et al. Am J Physiol Renal Physiol. 2017 Feb 1;312(2):F373-F374. doi: 10.1152/ajprenal.00499.2016. Epub 2016 Oct 19. Am J Physiol Renal Physiol. 2017. PMID: 27760773 Free PMC article. No abstract available.
Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury.
Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas MM, Sudhini YR, Wang X, Bouley R, Brown D, Pedro BP, Bane SL, Gupta V, Brinkkoetter PT, Hagmann H, Reiser J, Sever S. Mukherjee K, et al. Among authors: gupta v. Nat Commun. 2022 May 3;13(1):2422. doi: 10.1038/s41467-022-30101-4. Nat Commun. 2022. PMID: 35504916 Free PMC article.
A Podocyte-Based Automated Screening Assay Identifies Protective Small Molecules.
Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. Lee HW, et al. Among authors: gupta v. J Am Soc Nephrol. 2015 Nov;26(11):2741-52. doi: 10.1681/ASN.2014090859. Epub 2015 Apr 9. J Am Soc Nephrol. 2015. PMID: 25858967 Free PMC article.
Dynamin Autonomously Regulates Podocyte Focal Adhesion Maturation.
Gu C, Lee HW, Garborcauskas G, Reiser J, Gupta V, Sever S. Gu C, et al. Among authors: gupta v. J Am Soc Nephrol. 2017 Feb;28(2):446-451. doi: 10.1681/ASN.2016010008. Epub 2016 Jul 18. J Am Soc Nephrol. 2017. PMID: 27432739 Free PMC article.
Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.
Wei C, El Hindi S, Li J, Fornoni A, Goes N, Sageshima J, Maiguel D, Karumanchi SA, Yap HK, Saleem M, Zhang Q, Nikolic B, Chaudhuri A, Daftarian P, Salido E, Torres A, Salifu M, Sarwal MM, Schaefer F, Morath C, Schwenger V, Zeier M, Gupta V, Roth D, Rastaldi MP, Burke G, Ruiz P, Reiser J. Wei C, et al. Among authors: gupta v. Nat Med. 2011 Jul 31;17(8):952-60. doi: 10.1038/nm.2411. Nat Med. 2011. PMID: 21804539 Free PMC article.
7,704 results