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Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents.
Gupta SC, Kannappan R, Kim J, Rahman GM, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB. Gupta SC, et al. Mol Pharmacol. 2011 Nov;80(5):769-81. doi: 10.1124/mol.111.073122. Epub 2011 Jul 27. Mol Pharmacol. 2011. PMID: 21795584 Free PMC article.
Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.
Kim JH, Park B, Gupta SC, Kannappan R, Sung B, Aggarwal BB. Kim JH, et al. Among authors: gupta sc. Antioxid Redox Signal. 2012 Mar 1;16(5):413-27. doi: 10.1089/ars.2011.3982. Epub 2011 Dec 15. Antioxid Redox Signal. 2012. PMID: 22004570 Free PMC article.
3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.
Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB. Yadav VR, et al. Among authors: gupta sc. J Biol Chem. 2012 Jan 2;287(1):245-256. doi: 10.1074/jbc.M111.274613. Epub 2011 Nov 7. J Biol Chem. 2012. PMID: 22065587 Free PMC article. Retracted.
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
Gupta SC, Francis SK, Nair MS, Mo YY, Aggarwal BB. Gupta SC, et al. J Biol Chem. 2013 Nov 8;288(45):32343-32356. doi: 10.1074/jbc.M113.455188. Epub 2013 Sep 27. J Biol Chem. 2013. PMID: 24078627 Free PMC article.
693 results