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Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty.
Luo OJ, Lei W, Zhu G, Ren Z, Xu Y, Xiao C, Zhang H, Cai J, Luo Z, Gao L, Su J, Tang L, Guo W, Su H, Zhang ZJ, Fang EF, Ruan Y, Leng SX, Ju Z, Lou H, Gao J, Peng N, Chen J, Bao Z, Liu F, Chen G. Luo OJ, et al. Among authors: guo w. Nat Aging. 2022 Apr;2(4):348-364. doi: 10.1038/s43587-022-00198-9. Epub 2022 Apr 18. Nat Aging. 2022. PMID: 37117750
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.
Chen S, Fang L, Guo W, Zhou Y, Yu G, Li W, Dong K, Liu J, Luo Y, Wang B, Li Z, Zhao C, Sun Z, Shen Y, Leng Q, Zhou D, Han Z, Huang H, Ren H, Xu G, Feng X. Chen S, et al. Among authors: guo w. Nat Commun. 2018 Dec 13;9(1):5298. doi: 10.1038/s41467-018-07545-8. Nat Commun. 2018. PMID: 30546010 Free PMC article.
Lkb1 maintains Treg cell lineage identity.
Wu D, Luo Y, Guo W, Niu Q, Xue T, Yang F, Sun X, Chen S, Liu Y, Liu J, Sun Z, Zhao C, Huang H, Liao F, Han Z, Zhou D, Yang Y, Xu G, Cheng T, Feng X. Wu D, et al. Among authors: guo w. Nat Commun. 2017 Jun 16;8:15876. doi: 10.1038/ncomms15876. Nat Commun. 2017. PMID: 28621313 Free PMC article.
Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation.
Su X, Wang Q, Guo W, Pei X, Niu Q, Liu M, Liu Y, Chen S, Feng S, He Y, Yang D, Zhang R, Ma Q, Zhai W, Pang A, Wei J, Huang Y, Luo Y, Han M, Feng X, Jiang E. Su X, et al. Among authors: guo w. Cell Mol Immunol. 2020 May;17(5):483-495. doi: 10.1038/s41423-019-0312-3. Epub 2019 Oct 29. Cell Mol Immunol. 2020. PMID: 31664223 Free PMC article.
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