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KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19.
Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. Li J, et al. Among authors: guo j. Science. 2022 Apr 15;376(6590):eabi9591. doi: 10.1126/science.abi9591. Epub 2022 Apr 15. Science. 2022. PMID: 35258337 Free PMC article.
Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade.
Sun S, Luo L, Liang W, Yin Q, Guo J, Rush AM, Lv Z, Liang Q, Fischbach MA, Sonnenburg JL, Dodd D, Davis MM, Wang F. Sun S, et al. Among authors: guo j. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27509-27515. doi: 10.1073/pnas.1921223117. Epub 2020 Oct 19. Proc Natl Acad Sci U S A. 2020. PMID: 33077598 Free PMC article.
Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities.
Yin Q, Yu W, Grzeskowiak CL, Li J, Huang H, Guo J, Chen L, Wang F, Zhao F, von Boehmer L, Metzner TJ, Leppert JT, Chien YH, Kuo CJ, Davis MM. Yin Q, et al. Among authors: guo j. Proc Natl Acad Sci U S A. 2021 May 25;118(21):e2016168118. doi: 10.1073/pnas.2016168118. Proc Natl Acad Sci U S A. 2021. PMID: 34021082 Free PMC article.
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2.
Yin Q, Luo W, Mallajosyula V, Bo Y, Guo J, Xie J, Sun M, Verma R, Li C, Constantz CM, Wagar LE, Li J, Sola E, Gupta N, Wang C, Kask O, Chen X, Yuan X, Wu NC, Rao J, Chien YH, Cheng J, Pulendran B, Davis MM. Yin Q, et al. Among authors: guo j. Nat Mater. 2023 Mar;22(3):380-390. doi: 10.1038/s41563-022-01464-2. Epub 2023 Jan 30. Nat Mater. 2023. PMID: 36717665 Free PMC article.
NK-like CD8+ γδ T cells are expanded in persistent Mycobacterium tuberculosis infection.
Roy Chowdhury R, Valainis JR, Dubey M, von Boehmer L, Sola E, Wilhelmy J, Guo J, Kask O, Ohanyan M, Sun M, Huang H, Huang X, Nguyen PK, Scriba TJ, Davis MM, Bendall SC, Chien YH. Roy Chowdhury R, et al. Among authors: guo j. Sci Immunol. 2023 Mar 31;8(81):eade3525. doi: 10.1126/sciimmunol.ade3525. Epub 2023 Mar 31. Sci Immunol. 2023. PMID: 37000856 Free PMC article.
γδ T cell antigen receptor polyspecificity enables T cell responses to a broad range of immune challenges.
Guo J, Chowdhury RR, Mallajosyula V, Xie J, Dubey M, Liu Y, Li J, Wei YL, Palanski BA, Wang C, Qiu L, Ohanyan M, Kask O, Sola E, Kamalyan L, Lewis DB, Scriba TJ, Davis MM, Dodd D, Zeng X, Chien YH. Guo J, et al. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2315592121. doi: 10.1073/pnas.2315592121. Epub 2024 Jan 16. Proc Natl Acad Sci U S A. 2024. PMID: 38227652 Free PMC article.
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