Guo J - Search Results

1

Recent Advances in Multi-target Drugs Targeting Protein Kinases and Histone Deacetylases in Cancer Therapy.

Ling Y, Liu J, Qian J, Meng C, Guo J, Gao W, Xiong B, Ling C, Zhang Y. Ling Y, et al. Among authors: guo j. Curr Med Chem. 2020;27(42):7264-7288. doi: 10.2174/0929867327666200102115720. Curr Med Chem. 2020. PMID: 31894740 Review.

2

Design and Synthesis of C3-Substituted β-Carboline-Based Histone Deacetylase Inhibitors with Potent Antitumor Activities.

Ling Y, Feng J, Luo L, Guo J, Peng Y, Wang T, Ge X, Xu Q, Wang X, Dai H, Zhang Y. Ling Y, et al. Among authors: guo j. ChemMedChem. 2017 May 9;12(9):646-651. doi: 10.1002/cmdc.201700133. Epub 2017 Apr 20. ChemMedChem. 2017. PMID: 28425177

3

Development of novel bis-pyrazole derivatives as antitumor agents with potent apoptosis induction effects and DNA damage.

Dai H, Ge S, Guo J, Chen S, Huang M, Yang J, Sun S, Ling Y, Shi Y. Dai H, et al. Among authors: guo j. Eur J Med Chem. 2018 Jan 1;143:1066-1076. doi: 10.1016/j.ejmech.2017.11.098. Epub 2017 Dec 5. Eur J Med Chem. 2018. PMID: 29232583

4

Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells.

Ling Y, Guo J, Yang Q, Zhu P, Miao J, Gao W, Peng Y, Yang J, Xu K, Xiong B, Liu G, Tao J, Luo L, Zhu Q, Zhang Y. Ling Y, et al. Among authors: guo j. Eur J Med Chem. 2018 Jan 20;144:398-409. doi: 10.1016/j.ejmech.2017.12.061. Epub 2017 Dec 20. Eur J Med Chem. 2018. PMID: 29288941

5

A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects.

Miao JF, Peng YF, Chen S, Gao WJ, Yang QX, Zhu P, Guo J, Tao J, Luo L, Zhang Y, Ling Y. Miao JF, et al. Among authors: guo j. Eur J Pharmacol. 2018 Apr 5;824:78-88. doi: 10.1016/j.ejphar.2018.02.004. Epub 2018 Feb 9. Eur J Pharmacol. 2018. PMID: 29428472

6

Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities.

Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH. Ling Y, et al. Among authors: guo j. Eur J Med Chem. 2018 Jun 25;154:199-209. doi: 10.1016/j.ejmech.2018.05.025. Epub 2018 May 18. Eur J Med Chem. 2018. PMID: 29803003 Free PMC article.

7

Development of novel β-carboline-based hydroxamate derivatives as HDAC inhibitors with DNA damage and apoptosis inducing abilities.

Liu J, Wang T, Wang X, Luo L, Guo J, Peng Y, Xu Q, Miao J, Zhang Y, Ling Y. Liu J, et al. Among authors: guo j. Medchemcomm. 2017 Mar 29;8(6):1213-1219. doi: 10.1039/c6md00681g. eCollection 2017 Jun 1. Medchemcomm. 2017. PMID: 30108831 Free PMC article.

8

Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.

Yang F, Chen X, Song X, Ortega R, Lin X, Deng W, Guo J, Tu Z, Patterson AV, Smaill JB, Chen Y, Lu X. Yang F, et al. Among authors: guo j. J Med Chem. 2022 Nov 10;65(21):14809-14831. doi: 10.1021/acs.jmedchem.2c01319. Epub 2022 Oct 24. J Med Chem. 2022. PMID: 36278929

9

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors.

Hao C, Zhao F, Song H, Guo J, Li X, Jiang X, Huan R, Song S, Zhang Q, Wang R, Wang K, Pang Y, Liu T, Lu T, Huang W, Wang J, Lin B, He Z, Li H, Li F, Zhao D, Cheng M. Hao C, et al. Among authors: guo j. J Med Chem. 2018 Jan 11;61(1):265-285. doi: 10.1021/acs.jmedchem.7b01342. Epub 2017 Dec 30. J Med Chem. 2018. PMID: 29190083

10

Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors.

Guo J, Zhao F, Yin W, Zhu M, Hao C, Pang Y, Wu T, Wang J, Zhao D, Li H, Cheng M. Guo J, et al. Eur J Med Chem. 2018 Jul 15;155:197-209. doi: 10.1016/j.ejmech.2018.05.051. Epub 2018 Jun 1. Eur J Med Chem. 2018. PMID: 29886323

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