Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

337 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.
Liu Z, Leng EC, Gunasekaran K, Pentony M, Shen M, Howard M, Stoops J, Manchulenko K, Razinkov V, Liu H, Fanslow W, Hu Z, Sun N, Hasegawa H, Clark R, Foltz IN, Yan W. Liu Z, et al. Among authors: gunasekaran k. J Biol Chem. 2015 Mar 20;290(12):7535-62. doi: 10.1074/jbc.M114.620260. Epub 2015 Jan 12. J Biol Chem. 2015. PMID: 25583986 Free PMC article.
Asymmetrical Fc engineering greatly enhances antibody-dependent cellular cytotoxicity (ADCC) effector function and stability of the modified antibodies.
Liu Z, Gunasekaran K, Wang W, Razinkov V, Sekirov L, Leng E, Sweet H, Foltz I, Howard M, Rousseau AM, Kozlosky C, Fanslow W, Yan W. Liu Z, et al. Among authors: gunasekaran k. J Biol Chem. 2014 Feb 7;289(6):3571-90. doi: 10.1074/jbc.M113.513366. Epub 2013 Dec 5. J Biol Chem. 2014. PMID: 24311787 Free PMC article.
Biological Characterization of a Stable Effector Functionless (SEFL) Monoclonal Antibody Scaffold in Vitro.
Liu L, Jacobsen FW, Everds N, Zhuang Y, Yu YB, Li N, Clark D, Nguyen MP, Fort M, Narayanan P, Kim K, Stevenson R, Narhi L, Gunasekaran K, Bussiere JL. Liu L, et al. Among authors: gunasekaran k. J Biol Chem. 2017 Feb 3;292(5):1876-1883. doi: 10.1074/jbc.M116.748707. Epub 2016 Dec 19. J Biol Chem. 2017. PMID: 27994063 Free PMC article.
., Li, C., Salimi-Moosavi, H., Liu, L., Wen, J., Luo, Q., Daris, K., Buck, L., Miller, S., Ho, S-Y., Wang, W., Chen, Q., Walker, K., Wypych, J., Narhi, L., and Gunasekaran, K. (2017) J. ...
., Li, C., Salimi-Moosavi, H., Liu, L., Wen, J., Luo, Q., Daris, K., Buck, L., Miller, S., Ho, S-Y., Wang, W., Chen, Q., Walker, K …
A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.
Florio M, Gunasekaran K, Stolina M, Li X, Liu L, Tipton B, Salimi-Moosavi H, Asuncion FJ, Li C, Sun B, Tan HL, Zhang L, Han CY, Case R, Duguay AN, Grisanti M, Stevens J, Pretorius JK, Pacheco E, Jones H, Chen Q, Soriano BD, Wen J, Heron B, Jacobsen FW, Brisan E, Richards WG, Ke HZ, Ominsky MS. Florio M, et al. Among authors: gunasekaran k. Nat Commun. 2016 May 27;7:11505. doi: 10.1038/ncomms11505. Nat Commun. 2016. PMID: 27230681 Free PMC article.
Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide-Antibody Conjugates.
Biswas K, Nixey TE, Murray JK, Falsey JR, Yin L, Liu H, Gingras J, Hall BE, Herberich B, Holder JR, Li H, Ligutti J, Lin MJ, Liu D, Soriano BD, Soto M, Tran L, Tegley CM, Zou A, Gunasekaran K, Moyer BD, Doherty L, Miranda LP. Biswas K, et al. Among authors: gunasekaran k. ACS Chem Biol. 2017 Sep 15;12(9):2427-2435. doi: 10.1021/acschembio.7b00542. Epub 2017 Aug 28. ACS Chem Biol. 2017. PMID: 28800217
Engineering an IgG Scaffold Lacking Effector Function with Optimized Developability.
Jacobsen FW, Stevenson R, Li C, Salimi-Moosavi H, Liu L, Wen J, Luo Q, Daris K, Buck L, Miller S, Ho SY, Wang W, Chen Q, Walker K, Wypych J, Narhi L, Gunasekaran K. Jacobsen FW, et al. Among authors: gunasekaran k. J Biol Chem. 2017 Feb 3;292(5):1865-1875. doi: 10.1074/jbc.M116.748525. Epub 2016 Dec 19. J Biol Chem. 2017. PMID: 27994062 Free PMC article.
337 results