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Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease.
Gulbins A, Horstmann M, Daser A, Flögel U, Oeverhaus M, Bechrakis NE, Banga JP, Keitsch S, Wilker B, Krause G, Hammer GD, Spencer AG, Zeidan R, Eckstein A, Philipp S, Görtz GE. Gulbins A, et al. Front Endocrinol (Lausanne). 2023 Jun 26;14:1211473. doi: 10.3389/fendo.2023.1211473. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37435490 Free PMC article.
Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
Edwards MJ, Becker KA, Gripp B, Hoffmann M, Keitsch S, Wilker B, Soddemann M, Gulbins A, Carpinteiro E, Patel SH, Wilson GC, Pöhlmann S, Walter S, Fassbender K, Ahmad SA, Carpinteiro A, Gulbins E. Edwards MJ, et al. Among authors: gulbins a. J Biol Chem. 2020 Nov 6;295(45):15174-15182. doi: 10.1074/jbc.RA120.015249. Epub 2020 Sep 11. J Biol Chem. 2020. PMID: 32917722 Free PMC article.
Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells.
Carpinteiro A, Edwards MJ, Hoffmann M, Kochs G, Gripp B, Weigang S, Adams C, Carpinteiro E, Gulbins A, Keitsch S, Sehl C, Soddemann M, Wilker B, Kamler M, Bertsch T, Lang KS, Patel S, Wilson GC, Walter S, Hengel H, Pöhlmann S, Lang PA, Kornhuber J, Becker KA, Ahmad SA, Fassbender K, Gulbins E. Carpinteiro A, et al. Among authors: gulbins a. Cell Rep Med. 2020 Nov 17;1(8):100142. doi: 10.1016/j.xcrm.2020.100142. Epub 2020 Oct 29. Cell Rep Med. 2020. PMID: 33163980 Free PMC article.
Sphingolipids in thyroid eye disease.
Gulbins A, Görtz GE, Gulbins E, Eckstein A. Gulbins A, et al. Front Endocrinol (Lausanne). 2023 Apr 4;14:1170884. doi: 10.3389/fendo.2023.1170884. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37082124 Free PMC article. Review.
Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.
Gulbins A, Schumacher F, Becker KA, Wilker B, Soddemann M, Boldrin F, Müller CP, Edwards MJ, Goodman M, Caldwell CC, Kleuser B, Kornhuber J, Szabo I, Gulbins E. Gulbins A, et al. Mol Psychiatry. 2018 Dec;23(12):2324-2346. doi: 10.1038/s41380-018-0090-9. Epub 2018 Jul 23. Mol Psychiatry. 2018. PMID: 30038230 Free PMC article.
Role of Janus-Kinases in Major Depressive Disorder.
Gulbins A, Grassmé H, Hoehn R, Kohnen M, Edwards MJ, Kornhuber J, Gulbins E. Gulbins A, et al. Neurosignals. 2016;24(1):71-80. doi: 10.1159/000442613. Epub 2016 Aug 3. Neurosignals. 2016. PMID: 27487096 Free article.