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Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape.
Park DH, Liaw K, Bhojnagarwala P, Zhu X, Choi J, Ali AR, Bordoloi D, Gary EN, O'Connell RP, Kulkarni A, Guimet D, Smith T, Perales-Puchalt A, Patel A, Weiner DB. Park DH, et al. Among authors: guimet d. Mol Ther Oncolytics. 2023 Feb 16;28:249-263. doi: 10.1016/j.omto.2023.02.004. eCollection 2023 Mar 16. Mol Ther Oncolytics. 2023. PMID: 36915911 Free PMC article.
Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.
Patel A, Walters JN, Reuschel EL, Schultheis K, Parzych E, Gary EN, Maricic I, Purwar M, Eblimit Z, Walker SN, Guimet D, Bhojnagarwala P, Adeniji OS, Doan A, Xu Z, Elwood D, Reeder SM, Pessaint L, Kim KY, Cook A, Chokkalingam N, Finneyfrock B, Tello-Ruiz E, Dodson A, Choi J, Generotti A, Harrison J, Tursi NJ, Andrade VM, Dia Y, Zaidi FI, Andersen H, Abdel-Mohsen M, Lewis MG, Muthumani K, Kim JJ, Kulp DW, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE. Patel A, et al. Among authors: guimet d. Cell Rep Med. 2021 Oct 19;2(10):100420. doi: 10.1016/j.xcrm.2021.100420. Epub 2021 Sep 28. Cell Rep Med. 2021. PMID: 34604818 Free PMC article.
In vitro immunotherapy potency assays using real-time cell analysis.
Cerignoli F, Abassi YA, Lamarche BJ, Guenther G, Santa Ana D, Guimet D, Zhang W, Zhang J, Xi B. Cerignoli F, et al. Among authors: guimet d. PLoS One. 2018 Mar 2;13(3):e0193498. doi: 10.1371/journal.pone.0193498. eCollection 2018. PLoS One. 2018. PMID: 29499048 Free PMC article.