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Target-Guided Synthesis and Antiplasmodial Evaluation of a New Fluorinated 3-Alkylpyridine Marine Alkaloid Analog.
Barbosa CS, Guimarães DSM, Gonçalves AMMN, Barbosa MCDS, Alves E Costa ML, Nascimento Júnior CS, Guimarães L, Ribeiro-Viana RM, Dos Santos FV, Alves de Brito CF, de Pilla Varotti F, Ribeiro Viana GH. Barbosa CS, et al. Among authors: guimaraes dsm. ACS Omega. 2017 Nov 30;2(11):8264-8272. doi: 10.1021/acsomega.7b01302. Epub 2017 Nov 21. ACS Omega. 2017. PMID: 30023579 Free PMC article.
Improvement of antimalarial activity of a 3-alkylpiridine alkaloid analog by replacing the pyridine ring to a thiazole-containing heterocycle: Mode of action, mutagenicity profile, and Caco-2 cell-based permeability.
Guimarães DSM, de Sousa Luz LS, do Nascimento SB, Silva LR, de Miranda Martins NR, de Almeida HG, de Souza Reis V, Maluf SEC, Budu A, Marinho JA, Abramo C, Carmona AK, da Silva MG, da Silva GR, Kemmer VM, Butera AP, Ribeiro-Viana RM, Gazarini ML, Júnior CSN, Guimarães L, Dos Santos FV, de Castro WV, Viana GHR, de Brito CFA, de Pilla Varotti F. Guimarães DSM, et al. Eur J Pharm Sci. 2019 Oct 1;138:105015. doi: 10.1016/j.ejps.2019.105015. Epub 2019 Jul 22. Eur J Pharm Sci. 2019. PMID: 31344442
Nanoemulsion composed of 10-(4,5-dihydrothiazol-2-yl)thio)decan-1-ol), a synthetic analog of 3-alkylpiridine marine alkaloid: development, characterization, and antimalarial activity.
Silva MGD, Cardoso JF, Perasoli FB, Branquinho RT, Mourão RS, Tavares HDS, Xocaira MLCT, Guimarães DSM, Viana GHR, Varotti FP, Silva GRD. Silva MGD, et al. Among authors: guimaraes dsm. Eur J Pharm Sci. 2020 Aug 1;151:105382. doi: 10.1016/j.ejps.2020.105382. Epub 2020 May 26. Eur J Pharm Sci. 2020. PMID: 32470575